Design, synthesis and biological evaluation of 2,3-dihydro-5,6-dimethoxy-1H-inden-1-one and piperazinium salt hybrid derivatives as hAChE and hBuChE enzyme inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112140
Abstract: 2,3-Dihydro-5,6-dimethoxy-2-[4-(4-alkyl-4-methylpiperazinium-1-yl)benzylidine]-1H-inden-1-one halide salt derivatives as a novel donepezil hybrid analogs with the property of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzyme inhibition were designed and synthesized via N-alkylation reaction of 2,3-dihydro-5,6-dimethoxy-2-[4-(4-methylpiperazin-1-yl)benzylidene]-1H-inden-1-one with some alkyl halides. Biological… read more here.
Keywords: hbuche; salt; effect; inden one ... See more keywords
Synthesis and spectroscopic characterization of medicinal azo derivatives and metal complexes of Indandion
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2019.126885
Abstract: Abstract The development of new and more effective antibiotic agents is necessary for human health. Herein, we have prepared the series of azo-derivatives of 1,3-indandion and metal complexes (Cu2+, Zn2+, Ni2+ and Mn2+) with these… read more here.
Keywords: synthesis; azo derivatives; inden one; metal complexes ... See more keywords
[bmIm]OH catalyzed coupling: Green and efficient synthesis of 2,8 dioxacyclopenta [a] inden-3-one derivatives in an aqua media
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DOI: 10.1016/j.tetlet.2017.09.039
Abstract: Abstract An efficient recyclable [bmIm]OH catalyzed and aqua mediated eco-compatible synthesis of biologically versatile 2,8 dioxacyclopenta [ a ] inden-3-one derivatives. Combination of ionic liquid and water has emerged out as a powerful synthetic tool… read more here.
Keywords: one derivatives; bmim catalyzed; dioxacyclopenta inden; inden one ... See more keywords