Cardiotonic steroids induce vascular fibrosis via pressure-independent mechanism in NaCl-loaded diabetic rats.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of cardiovascular pharmacology"
DOI: 10.1097/fjc.0000000000000730
Abstract: Endogenous cardiotonic steroid, marinobufagenin (MBG), induces Fli1-dependent tissue fibrosis. We hypothesized that an increase in MBG initiates the development of aortic fibrosis in salt-loaded rats with type 2 diabetes mellitus (DM2) via pressure-independent mechanism.DM2 was… read more here.
Keywords: pressure independent; via pressure; mbg; fibrosis ... See more keywords
Schisandrol B and schisandrin B inhibit TGFβ1-mediated NF-κB activation via a Smad-independent mechanism
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.23213
Abstract: Aberrant transforming growth factor β1 (TGFβ1) signaling plays a pathogenic role in the development of vascular fibrosis. We have reported that Schisandra chinensis fruit extract (SCE), which has been used as a traditional oriental medicine,… read more here.
Keywords: smad independent; tgf; independent mechanism; mediated activation ... See more keywords