Zinc Oxide nanoparticles induce oxidative and proteotoxic stress in ovarian cancer cells and trigger apoptosis Independent of p53-mutation status.
Sign Up to like & getrecommendations! Published in 2019 at "Applied surface science"
DOI: 10.1016/j.apsusc.2019.05.099
Abstract: Ovarian cancer continues to be the most lethal among gynecological malignancies and the major cause for cancer-associated mortality among women. Limitations of current ovarian cancer therapeutics is highlighted by the high frequency of drug-resistant recurrent… read more here.
Keywords: ovarian cancer; cancer cells; cancer; independent p53 ... See more keywords
Quinacrine upregulates p21/p27 independent of p53 through autophagy-mediated downregulation of p62-Skp2 axis in ovarian cancer
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-20531-w
Abstract: We have previously shown that the anti-malarial compound Quinacrine (QC) inhibits ovarian cancer (OC) growth by modulating autophagy. In the present study we extended these studies to identify the molecular pathways regulated by QC to… read more here.
Keywords: skp2; independent p53; p62; downregulation ... See more keywords