Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09309-4
Abstract: In embryonic stem cells, promoters of key lineage-specific differentiation genes are found in a bivalent state, having both activating H3K4me3 and repressive H3K27me3 histone marks, making them poised for transcription upon loss of H3K27me3. Whether… read more here.
Keywords: initiating cells; self renewal; differentiation; indian hedgehog ... See more keywords
Indian Hedgehog release from TNF-activated renal epithelia drives local and remote organ fibrosis
Sign Up to like & getrecommendations! Published in 2023 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abn0736
Abstract: Progressive fibrosis is a feature of aging and chronic tissue injury in multiple organs, including the kidney and heart. Glioma-associated oncogene 1 expressing (Gli1+) cells are a major source of activated fibroblasts in multiple organs,… read more here.
Keywords: tnf; gli1; indian hedgehog; release ... See more keywords
The South Indian hedgehog Paraechinus nudiventris (Horsfield, 1851): review of distribution data, additional localities and comments on habitat and conservation
Sign Up to like & getrecommendations! Published in 2018 at "Mammalia"
DOI: 10.1515/mammalia-2018-0128
Abstract: Abstract The South Indian hedgehog Paraechinus nudiventris (Horsfield, 1851) is one of the least studied, small mammals endemic to India. Although it is listed as Least Concern by the International Union for Conservation of Nature… read more here.
Keywords: hedgehog paraechinus; nudiventris horsfield; south indian; indian hedgehog ... See more keywords
Decreased Indian hedgehog signaling activates autophagy in endometriosis and adenomyosis.
Sign Up to like & getrecommendations! Published in 2021 at "Reproduction"
DOI: 10.1530/rep-20-0172
Abstract: Indian hedgehog (Ihh) signaling regulates endometrial receptivity and is an indispensable mediator of embryonic implantation. Hedgehog signaling is known to regulate autophagy, and aberrant regulation of autophagy is critically implicated in the pathogenesis of endometriosis… read more here.
Keywords: adenomyosis; hedgehog signaling; endometriosis adenomyosis; indian hedgehog ... See more keywords
TL1A mediates fibroblast-like synoviocytes migration and Indian Hedgehog signaling pathway via TNFR2 in patients with rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2018 at "European Cytokine Network"
DOI: 10.1684/ecn.2018.0405
Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joints inflammation. One of the aggressive characteristics of RA fibroblast-like synoviocytes (FLS) is the tendency for migration in the local environment, which plays a central… read more here.
Keywords: signaling pathway; hedgehog signaling; indian hedgehog; tl1a ... See more keywords
Knockdown of Indian hedgehog protein induces an inhibition of cell growth and differentiation in osteoblast MC3T3-E1 cells
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2017.7669
Abstract: Indian hedgehog protein (Ihh) is evolutionarily conserved and serves important roles in controlling the differentiation of progenitor cells into osteoblasts. Ihh null mutant mice exhibit a failure of osteoblast development in endochondral bone. Although studies… read more here.
Keywords: ihh; cell; differentiation; indian hedgehog ... See more keywords