β-III Tubulin Levels Determine the Neurotoxicity Induced by Colchicine-Site Binding Agent Indibulin.
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DOI: 10.1021/acschemneuro.2c00324
Abstract: Indibulin, a microtubule-depolymerizing agent, produces minimal neurotoxicity in animals. It is also less cytotoxic toward differentiated neuronal cells than undifferentiated cells. We found that the levels of β-III tubulin, acetylated tubulin, and polyglutamylated tubulin were… read more here.
Keywords: tubulin; iii tubulin; indibulin; colchicine site ... See more keywords