PP05 Effect Modifiers In Indirect Treatment Comparisons: Guidance Is Needed To Ensure An Unbiased Identification In Decision-Making
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DOI: 10.1017/s0266462322001507
Abstract: Introduction Unadjusted effect modifiers (EM) in indirect treatment comparisons (ITC) can produce biased and uncertain results in health technology assessments (HTA). Even though research on advanced ITC methods to adjust for EMs has attracted much… read more here.
Keywords: guidance; indirect treatment; modifiers indirect; treatment comparisons ... See more keywords
Tezepelumab compared with other biologics for the treatment of severe asthma: a systematic review and indirect treatment comparison
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DOI: 10.1080/13696998.2022.2074195
Abstract: Abstract Aims To compare the efficacy of tezepelumab with other approved biologics via indirect treatment comparisons (ITCs) in patients aged ≥ 12 years with severe uncontrolled asthma. Materials and methods Data from randomized controlled trials (RCTs)… read more here.
Keywords: tezepelumab; treatment comparison; review; indirect treatment ... See more keywords
Methodological challenges in indirect treatment comparisons: spotlight on a recent comparison of long-acting injectable aripiprazole versus paliperidone palmitate in the treatment of schizophrenia
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DOI: 10.1097/yic.0000000000000215
Abstract: In a recent study, an indirect treatment comparison was performed to examine the relative efficacy and tolerability of aripiprazole once monthly and paliperidone palmitate once monthly. The authors concluded that the results may suggest relative… read more here.
Keywords: treatment; paliperidone palmitate; indirect treatment; comparison ... See more keywords
Indirect treatment comparisons including network meta-analysis: Lenvatinib plus everolimus for the second-line treatment of advanced/metastatic renal cell carcinoma
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DOI: 10.1371/journal.pone.0212899
Abstract: Background In the absence of clinical trials providing direct efficacy results, this study compares different methods of indirect treatment comparison (ITC), and their respective impacts on efficacy estimates for lenvatinib (LEN) plus everolimus (EVE) combination… read more here.
Keywords: pfs; treatment; len eve; plus everolimus ... See more keywords
Comparación indirecta ajustada de anticuerpos monoclonales contra el péptido relacionado con el gen de la calcitonina en migraña crónica
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DOI: 10.7399/fh.11419
Abstract: Objective: New monoclonal antibodies against the calcitonin generelated peptide pathway have recently been developed for the prevention of migraine. The aim of this study is to compare the efficacy of monoclonal antibodies against the calcitonin generelated peptide pathway… read more here.
Keywords: treatment; migraine; randomized clinical; treatment comparison ... See more keywords