Efficient Bioproduction of Indigo and Indirubin by Optimizing a Novel Terpenoid Cyclase XiaI in Escherichia coli
Sign Up to like & getrecommendations! Published in 2021 at "ACS Omega"
DOI: 10.1021/acsomega.1c02679
Abstract: Blue indigo dye, an important natural colorant, is used for textiles and food additives worldwide, while another red isomer, indirubin, is the major active ingredient of a traditional Chinese medicine named “Danggui Longhui Wan” for… read more here.
Keywords: indirubin; novel terpenoid; productivity; terpenoid cyclase ... See more keywords
All-Red-Light Photoswitching of Indirubin Controlled by Supramolecular Interactions.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c08206
Abstract: Red-light responsiveness of photoswitches is a highly desired property for many important application areas such as biology or material sciences. The main approach to elicit this property uses strategic substitution of long-known photoswitch motives such… read more here.
Keywords: indirubin; red light; light photoswitching; photoswitching indirubin ... See more keywords
Therapeutic effect of indirubin-loaded bovine serum albumin nanoparticules on ulcerative colitis.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d1bm01896e
Abstract: Indirubin is considered to have promising potential in the treatment of ulcerative colitis (UC). However, poor aqueous solubility and low bioavailability limit its clinical application. We produced indirubin-loaded bovine serum albumin nanoparticles (INPs) and characterized… read more here.
Keywords: indirubin; effect; indirubin loaded; colitis ... See more keywords
A traditional Chinese remedy points to a natural skin habitat: indirubin (indigo naturalis) for psoriasis and the Malassezia metabolome
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Dermatology"
DOI: 10.1111/bjd.16807
Abstract: We read with extreme interest the evidence for an impressively high, comparable to current systemic therapies, dose related efficacy of indirubin in plaque psoriasis.1 Lin and co-authors1 appropriately discuss their results, yet we would like… read more here.
Keywords: indirubin; traditional chinese; chinese remedy; malassezia metabolome ... See more keywords
Transdermal Delivery of Indirubin-Loaded Microemulsion Gel: Preparation, Characterization and Anti-Psoriatic Activity
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073798
Abstract: Psoriasis is an immune disease caused by rapid and incomplete differentiation of skin basal cells. Natural products such as indirubin have historically served as excellent sources for the treatments of psoriasis. However, the poor solubility… read more here.
Keywords: indirubin; microemulsion; indirubin loaded; transdermal delivery ... See more keywords
A Sensitive LC-MS/MS Method for the Simultaneous Determination of Two Thia-Analogous Indirubin N-Glycosides and Indirubin-3′-Monoxime in Plasma and Cell Culture Medium
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27093031
Abstract: Indirubin was identified as an active component of Danggui Longhui Wan, an herbal mixture used in traditional Chinese medicine, and showed anticancer activity in clinical trials in patients with chronic leukemia. Investigations on the mechanisms… read more here.
Keywords: indirubin; indirubin glycosides; cell culture; plasma cell ... See more keywords