Next-generation protein sequencing and individual ion mass spectrometry enable complementary analysis of interleukin-6
Sign Up to like & getrecommendations! Published in 2025 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-025-06120-7
Abstract: The vast complexity of the proteome currently overwhelms any single analytical technology in capturing the full spectrum of proteoform diversity. In this study, we evaluated the complementarity of two cutting-edge proteomic technologies—single-molecule protein sequencing and… read more here.
Keywords: ion mass; mass spectrometry; individual ion; protein sequencing ... See more keywords
Automated Control of Injection Times for Unattended Acquisition of Multiplexed Individual Ion Mass Spectra.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c03495
Abstract: Charge detection mass spectrometry (CDMS) provides mass domain spectra of large and highly heterogeneous analytes. Over the past few years, we have multiplexed CDMS on Orbitrap instruments, an approach termed Individual Ion Mass Spectrometry (I2MS).… read more here.
Keywords: ion mass; individual ion; injection times; ion ... See more keywords
Individual Ion Mass Spectrometry Enhances the Sensitivity and Sequence Coverage of Top Down Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.9b00797
Abstract: Charge detection mass spectrometry (CDMS) is mainly utilized to determine the mass of intact molecules. Previous applications of CDMS have determined the mass-to-charge ratio and charge of large polymers, DNA molecules, and native protein complexes,… read more here.
Keywords: ion mass; mass; mass spectrometry; individual ion ... See more keywords
Large Individual Ion FTICR Measurements from the Mid-1990s Using Reactions for Charge Determination Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Society for Mass Spectrometry"
DOI: 10.1021/jasms.2c00329
Abstract: This article discusses from a personal and present-day perspective the first studies of large highly charged individual molecular ions that were conducted using electrospray ionization with Fourier transform ion cyclotron resonance MS in the mid-1990s.… read more here.
Keywords: mass spectrometry; charge determination; individual ion; mass ... See more keywords