Evaluation of Anti-Epileptic Effect of New Indole Derivatives by Estimation of Biogenic Amines Concentrations in Rat Brain.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-56246-9_3
Abstract: The new heterocyclic compounds are used to treat epilepsy. In the present work new indole derivatives i.e. 5-[2(3)-di alkyl amino alkoxy] Indole 2,3-di-one derivatives are synthesized and characterized and these compounds was subjected to acute… read more here.
Keywords: indole; amino ethoxy; ethoxy indole; dimethyl amino ... See more keywords
Dual effects of the tryptophan-derived bacterial metabolite indole on colonic epithelial cell metabolism and physiology: comparison with its co-metabolite indoxyl sulfate.
Sign Up to like & getrecommendations! Published in 2022 at "Amino acids"
DOI: 10.1007/s00726-021-03122-4
Abstract: Indole, which is produced by the intestinal microbiota from L-tryptophan, is recovered at millimolar concentrations in the human feces. Indoxyl sulfate (IS), the main indole co-metabolite, can be synthesized by the host tissues. Although indole… read more here.
Keywords: colonic epithelial; indole; physiology; cell ... See more keywords
Separation of indole by designed ionic liquids with dual functional chemical sites: Mechanism exploration and experimental validation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of environmental chemical engineering"
DOI: 10.1016/j.jece.2021.105971
Abstract: Abstract As a hopeful solvent, ionic liquids with tremendous combination of functional chemical sites in the cations and anions can make the separation process efficiently and selectively. Thus, to test the effect of the functional… read more here.
Keywords: dual functional; chemical; separation; chemical sites ... See more keywords
An insight into the recent developments in anti-infective potential of indole and associated hybrids
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2022.132808
Abstract: Prevention, accurate diagnosis, and effective treatment of infections are the main challenges in the overall management of infectious diseases. The best example is the ongoing SARs-COV-2(COVID-19) pandemic; the entire world is extremely worried about at… read more here.
Keywords: recent developments; associated hybrids; indole associated; anti infective ... See more keywords
New chiral ferrocene/indole-based diphosphine ligands for Rh-catalyzed asymmetric hydrogenation of functionalized olefins
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2020.151860
Abstract: Abstract Convenient synthesis of a new family of chiral ferrocene/indole-based diphosphine ligands, (Rc,Rp)-IndoFerroPhos (L), from (Sc,Rp)-PPFA and 2-(diphenylphosphino)indole has been described. These new ligands exhibited high efficiency in the Rh-catalyzed asymmetric hydrogenation of functionalized olefins… read more here.
Keywords: diphosphine ligands; based diphosphine; chiral ferrocene; indole ... See more keywords
Organocatalytic Atroposelective Synthesis of Indole Derivatives Bearing Axial Chirality: Strategies and Applications.
Sign Up to like & getrecommendations! Published in 2022 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.2c00465
Abstract: ConspectusCatalytic atroposelective syntheses of axially chiral compounds have stimulated extensive interest in multiple communities, such as synthetic chemistry, biochemistry, and materials science, because of the intriguing characteristics of atropisomerism. In particular, atropisomeric indole derivatives, which… read more here.
Keywords: chemistry; indole derivatives; indole; axial chirality ... See more keywords
Fermentative Indole Production via Bacterial Tryptophan Synthase Alpha Subunit and Plant Indole-3-Glycerol Phosphate Lyase Enzymes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Agricultural and Food Chemistry"
DOI: 10.1021/acs.jafc.2c01042
Abstract: Indole is produced in nature by diverse organisms and exhibits a characteristic odor described as animal, fecal, and floral. In addition, it contributes to the flavor in foods, and it is applied in the fragrance… read more here.
Keywords: tryptophan synthase; indole glycerol; indole production; indole ... See more keywords
In Silico Study of the Radical Scavenging Activities of Natural Indole-3-Carbinols
Sign Up to like & getrecommendations! Published in 2020 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.9b00917
Abstract: Enzymatic hydrolysis of indole glucosinolates in the human body yields the Indole-3-carbinol family of compounds (I3Cs). I3Cs are implicated in the self-healing processes of the human body and thus used as over the counter dietary… read more here.
Keywords: indole carbinol; indole; natural indole; radical scavenging ... See more keywords
Visible-Light-Irradiated Cascade Reaction of Indole-Tethered Alkenes to Access Tetracyclic Tetrahydro-γ-carbolines.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00626
Abstract: A series of indole-derived alkenes have been designed and applied in a photocatalytic cascade reaction with bromodifluoroacetate esters, affording an unknown type of tetracyclic tetrahydro-γ-carboline derivative in up to 90% yields. Mechanistic studies suggest that… read more here.
Keywords: tetrahydro carboline; reaction; tetracyclic tetrahydro; indole ... See more keywords
Pd-Catalyzed C-H Functionalization of Indole-Containing Alkene-Tethered Aryl Halides with Alkynes To Construct Indole Alkaloid Scaffolds.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00882
Abstract: A convenient and straightforward approach for the construction of indole alkaloid scaffolds from indole-containing alkene-tethered aryl halides and alkynes through a sequential C-H activation, five-membered palladacycle formation, and alkyne insertion process has been described. The… read more here.
Keywords: indole alkaloid; containing alkene; indole; alkene tethered ... See more keywords
Palladium-Catalyzed Direct C-H Glycosylation of Free (N-H) Indole and Tryptophan by Norbornene-Mediated Regioselective C-H Activation.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02537
Abstract: We describe the palladium-catalyzed direct C-H glycosylation of free N-H indole or tryptophan for the stereoselective synthesis of 2-glycosylindoles and tryptophan-C-glycosides. This reaction relies on the ortho-directing transient mediator norbornene, which underwent regioselective C-H functionalization… read more here.
Keywords: palladium catalyzed; indole; catalyzed direct; direct glycosylation ... See more keywords