Overexpression of tryptophan decarboxylase and strictosidine synthase enhanced terpenoid indole alkaloid pathway activity and antineoplastic vinblastine biosynthesis in Catharanthus roseus
Sign Up to like & getrecommendations! Published in 2018 at "Protoplasma"
DOI: 10.1007/s00709-018-1233-1
Abstract: Terpenoid indole alkaloid (TIA) biosynthetic pathway of Catharanthus roseus possesses the major attention in current metabolic engineering efforts being the sole source of highly expensive antineoplastic molecules vinblastine and vincristine. The entire TIA pathway is… read more here.
Keywords: biosynthesis; tia; pathway; roseus ... See more keywords
Indole Alkaloid Synthesis via Radical Cascade Reactions
Sign Up to like & getrecommendations! Published in 2017 at "Chem"
DOI: 10.1016/j.chempr.2017.05.012
Abstract: Mr. Xiaobei Wang is currently a fifth-year PhD student within Prof. Yong Qin's research group at Sichuan University. He was born in Anhui Province and obtained his BSc degree in pharmacy from Sichuan University in… read more here.
Keywords: synthesis; alkaloid synthesis; via radical; sichuan university ... See more keywords
Methyl jasmonate and salicylic acid elicit indole alkaloid production and modulate antioxidant defence and biocidal properties in Rauvolfia serpentina Benth. ex Kurz. in vitro cultures
Sign Up to like & getrecommendations! Published in 2020 at "South African Journal of Botany"
DOI: 10.1016/j.sajb.2020.07.020
Abstract: Abstract In the present report, the effect of methyl jasmonate (MJ) and salicyclic acid (SA) elicitation, on the indole alkaloid production from micropropagated culture of the endangered Ayurvedic medicinal plant Rauvolfia serpentina Benth. ex Kurz,… read more here.
Keywords: methyl jasmonate; rauvolfia serpentina; alkaloid production; vitro ... See more keywords
Alstobrogaline, an unusual pentacyclic monoterpenoid indole alkaloid with aldimine and aldimine-N-oxide moieties from Alstonia scholaris
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.02.018
Abstract: Abstract Alstobrogaline ( 1 ), an unusual monoterpenoid indole alkaloid incorporating a third N atom and possessing two aldimine functions, with one being in the form of N -oxide, was isolated from the leaves of… read more here.
Keywords: indole alkaloid; aldimine; alstonia scholaris; monoterpenoid indole ... See more keywords
Rapid and unambiguous assignment of proton-deficient N-acyl amidine indole alkaloid by a combination of calculation methods
Sign Up to like & getrecommendations! Published in 2021 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2021.152949
Abstract: Abstract The unprecedently rearranged 6/5/8/6/5 pentacyclic monoterpenoid indole alkaloid voafriamidine from Voacanga africana contains an uncommon N-acyl amidine structural motif that forms a unique 2,4-diazatricycle-[6,5,11,8,03,7] tetradecane skeleton. Despite the lack of proper NMR correlations for… read more here.
Keywords: acyl amidine; indole alkaloid; combination; unambiguous assignment ... See more keywords
Gelstriamine A, a Triamino Monoterpene Indole Alkaloid with a Caged 6/5/7/6/6/5 Scaffold and Analgesic Alkaloids from Gelsemium elegans Stems.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.1c00062
Abstract: A novel triamino monoterpene indole alkaloid with an unprecedented skeleton, gelstriamine A (1), four new monoterpene indole alkaloids (2-5), and 12 known analogues (6-17) were isolated from Gelsemium elegans. The structures of 1-5 were established… read more here.
Keywords: monoterpene indole; triamino monoterpene; gelsemium elegans; indole alkaloid ... See more keywords
Eugeniifoline, a Pentacyclic Indole Alkaloid from Leuconotis eugeniifolia, and Configurational Revision of Synthetic Eugeniifoline Isolated from a Diversity-Enhanced Extract.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.2c00731
Abstract: Eugeniifoline (1), a pentacyclic indole alkaloid with a five-membered ring E, was isolated for the first time as a natural product from the stem-bark extract of Leuconotis eugeniifolia. Eugeniifoline (1) was previously reported as a… read more here.
Keywords: indole alkaloid; diversity enhanced; eugeniifoline pentacyclic; leuconotis eugeniifolia ... See more keywords
Pd-Catalyzed C-H Functionalization of Indole-Containing Alkene-Tethered Aryl Halides with Alkynes To Construct Indole Alkaloid Scaffolds.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00882
Abstract: A convenient and straightforward approach for the construction of indole alkaloid scaffolds from indole-containing alkene-tethered aryl halides and alkynes through a sequential C-H activation, five-membered palladacycle formation, and alkyne insertion process has been described. The… read more here.
Keywords: indole alkaloid; containing alkene; indole; alkene tethered ... See more keywords
Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels–Alderase
Sign Up to like & getrecommendations! Published in 2019 at "Nature Chemistry"
DOI: 10.1038/s41557-019-0326-6
Abstract: Prenylated indole alkaloids such as the calmodulin-inhibitory malbrancheamides and anthelmintic paraherquamides possess great structural diversity and pharmaceutical utility. Here, we report complete elucidation of the malbrancheamide biosynthetic pathway accomplished through complementary approaches. These include a… read more here.
Keywords: alkaloid biogenesis; diels alderase; fungal indole; reductase diels ... See more keywords
Beshanzuamide A, an unprecedented prenylated indole alkaloid produced by Aspergillus sp. Y-2 from the critically endangered conifer Abies beshanzuensis
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DOI: 10.1039/d2ra01578a
Abstract: A structurally unprecedented prenylated indole alkaloid, beshanzuamide A (1), together with five known analogues (2–6) were isolated and identified from the endophytic fungus derived from the needles of the critically endangered conifer Abies beshanzuensis. The… read more here.
Keywords: unprecedented prenylated; indole alkaloid; conifer abies; endangered conifer ... See more keywords
A new indole alkaloid from the traditional Chinese medicine Chansu
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Asian Natural Products Research"
DOI: 10.1080/10286020.2017.1339697
Abstract: Abstract A new indole alkaloid N′-formylserotonin (1), along with five known indole alkaloids N′-methylserotonin (2), 5-hydroxy-1H-indole-3-carbaldehyde (3), N-acetylserotonin (4), 6-hydroxy-1-oxo-3,4-dihydro-β-carboline (5), and bufoserotoin C (6), were isolated from the water extract of traditional Chinese medicine… read more here.
Keywords: medicine; traditional chinese; chinese medicine; new indole ... See more keywords