Attenuating effect of Indole-3-Carbinol on gold nanoparticle induced hepatotoxicity in rats
Sign Up to like & getrecommendations! Published in 2020 at "Arabian Journal of Chemistry"
DOI: 10.1016/j.arabjc.2020.09.035
Abstract: Abstract Indole-3-carbinol (I3C) is a plant based compound present in vegetables mostly belonging to cruciferous family. I3C has been shown to possess anticancer, antioxidant and anti-inflammatory properties. Humans are increasingly being exposed to GNPs due… read more here.
Keywords: i3c; indole carbinol; gnps; effects i3c ... See more keywords
Nanocapsules improve indole‐3‐carbinol photostability and prolong its antinociceptive action in acute pain animal models
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2017.09.050
Abstract: ABSTRACT This study aimed the development of nanocapsules (NCs) for oral indole‐3‐carbinol (I3C) administration and evaluation of antinociceptive potential of this compound in its two forms, free and nanoencapsulated, using acute pain models. NCs showed… read more here.
Keywords: antinociceptive action; acute; action acute; acute pain ... See more keywords
In Silico Study of the Radical Scavenging Activities of Natural Indole-3-Carbinols
Sign Up to like & getrecommendations! Published in 2020 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.9b00917
Abstract: Enzymatic hydrolysis of indole glucosinolates in the human body yields the Indole-3-carbinol family of compounds (I3Cs). I3Cs are implicated in the self-healing processes of the human body and thus used as over the counter dietary… read more here.
Keywords: indole carbinol; indole; natural indole; radical scavenging ... See more keywords
Maximizing the value of indole-3-carbinol, from its distribution in dietary sources, health effects, metabolism, extraction, and analysis in food and biofluids.
Sign Up to like & getrecommendations! Published in 2023 at "Critical reviews in food science and nutrition"
DOI: 10.1080/10408398.2023.2197065
Abstract: Indole-3-carbinol (I3C) is a major dietary component produced in Brassica vegetables from glucosinolates (GLS) upon herbivores' attack. The compound is gaining increasing interest due to its anticancer activity. However, reports about improving its level in… read more here.
Keywords: metabolism; health; extraction; indole carbinol ... See more keywords
Indole-3-carbinol ameliorated the isoproterenol-induced myocardial infarction via multimodal mechanisms in Wistar rats.
Sign Up to like & getrecommendations! Published in 2022 at "Natural product research"
DOI: 10.1080/14786419.2022.2041632
Abstract: The present study investigated the cardioprotection of Indole-3-carbinol on isoproterenol (ISO)-induced myocardial infarction in Wistar rats. I3C treatment significantly reduced the prolongation of the QRS complex, QT interval, and ST-segment elevation. I3C was also able… read more here.
Keywords: wistar rats; infarction; indole carbinol; myocardial infarction ... See more keywords
Effects of indole-3-carbinol on steroid hormone profile and tumor progression in a mice model of canine inflammatory mammarycancer
Sign Up to like & getrecommendations! Published in 2018 at "BMC Cancer"
DOI: 10.1186/s12885-018-4518-z
Abstract: BackgroundIndole-3-carbinol, derived from Cruciferous vegetables is an estrogen receptor antagonist considered a preventive agent that is naturally present in diet. There are no previous studies on its effects in human inflammatory breast cancer or canine… read more here.
Keywords: canine inflammatory; indole carbinol; model; cancer ... See more keywords
Indole-3-Carbinol, a Phytochemical Aryl Hydrocarbon Receptor-Ligand, Induces the mRNA Overexpression of UBE2L3 and Cell Proliferation Arrest
Sign Up to like & getrecommendations! Published in 2022 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb44050139
Abstract: Cervical cancer (CC) is one of the most common cancers in women, and is linked to human papillomavirus (HPV) infection. The virus oncoprotein E6 binds to p53, resulting in its degradation and allowing uncontrolled cell… read more here.
Keywords: hydrocarbon receptor; cell; cell proliferation; indole carbinol ... See more keywords
Indole-3-Carbinol Inhibits the Growth of Endometriotic Lesions by Suppression of Microvascular Network Formation
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14224940
Abstract: Endometriosis represents an estrogen-dependent disorder with a complex pathophysiology. Phytochemicals are promising candidates for endometriosis therapy, because they simultaneously target different cellular processes involved in the pathogenesis of endometriosis. Herein, we analyzed whether indole-3-carbinol (I3C)… read more here.
Keywords: growth; endometriotic lesions; formation; i3c ... See more keywords
Synthetic Methodologies and Therapeutic Potential of Indole-3-Carbinol (I3C) and Its Derivatives
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16020240
Abstract: Indole-3-carbinol (I3C) is a natural product contained in vegetables belonging to the Brassicaceae family and has been studied in recent decades for its biological and pharmacological properties. Herein, we will analyze: (1) the biosynthetic processes… read more here.
Keywords: carbinol i3c; synthetic methodologies; i3c derivatives; methodologies therapeutic ... See more keywords