Dynamic kinetic resolution of γ,γ-disubstituted indole 2-carboxaldehydes via NHC-Lewis acid cooperative catalysis for the synthesis of tetracyclic ε-lactones
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DOI: 10.1039/d2sc03745a
Abstract: The ubiquity of ε-lactones in various biologically active compounds inspired the development of efficient and enantioselective routes to these target compounds. Described herein is the enantioselective synthesis of indole-fused ε-lactones by the N-heterocyclic carbene (NHC)-Lewis… read more here.
Keywords: indole carboxaldehydes; acid cooperative; disubstituted indole; dynamic kinetic ... See more keywords