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Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-2983-3
Abstract: Hyperlipidemia is a known cause of coronary vascular diseases, which is a major cause of death in many parts of the world. Targeting several pathways that lead to increase in lipid profiles is of great…
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Keywords:
benzoylphenyl indole;
gene expression;
indole carboxamide;
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Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.104960
Abstract: New EGFR inhibitor series of fifteen 5-chloro-3-hydroxymethyl-indole-2-carboxamide derivatives has been designed, synthesized, and tested for antiproliferative activity against a panel of cancer cell lines. The results showed that p-substituted phenethyl derivatives 10, 11, 13, 15…
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Keywords:
egfr;
indole carboxamide;
hydroxymethyl indole;
antiproliferative activity ... See more keywords
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Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c00726
Abstract: Liver fructose-1,6-bisphosphatase (FBPase) is a key enzyme in the gluconeogenesis pathway. Inhibiting FBPase activity represents a potential treatment for type 2 diabetes mellitus. A series of novel N-arylsulfonyl-4-arylamino-indole-2-carboxamide derivatives have been disclosed as FBPase inhibitors.…
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Keywords:
carboxamide derivatives;
indole carboxamide;
ray crystal;
fructose bisphosphatase ... See more keywords
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Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.1070080
Abstract: The latest world malaria report revealed that human deaths caused by malaria are currently on the rise and presently stood at over 627,000 per year. In addition, more than 240 million people have the infection…
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Keywords:
quinolinyl oxamide;
development;
oxamide derivative;
carboxamide derivative ... See more keywords