Indole-coumarin-thiadiazole hybrids: An appraisal of their MCF-7 cell growth inhibition, apoptotic, antimetastatic and computational Bcl-2 binding potential.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.05.032
Abstract: Cancer therapeutic potential of thiadiazole hybrids incorporating pharmacologically active indole and coumarin moieties have not been explored much. In the current investigation, three new thiadiazole hybrids with spacers of varying lengths linking indole and thiadiazole… read more here.
Keywords: bcl; indole coumarin; thiadiazole hybrids; apoptosis ... See more keywords
Indole and Coumarin Derivatives Targeting EEF2K in Aβ Folding Reporter Cells
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.16300
Abstract: Misfolding and accumulation of amyloid‐β (Aβ) in the brains of patients with Alzheimer's disease (AD) lead to neuronal loss through various mechanisms, including the downregulation of eukaryotic elongation factor 2 (EEF2) protein synthesis signaling. This… read more here.
Keywords: phosphorylation; folding reporter; eef2k; coumarin derivatives ... See more keywords