Synthesis, Antibacterial Activity Evaluation and Mechanism Exploration of Indole Derivatives Containing [1,2,4]Triazole Moiety
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.70112
Abstract: Bacterial diseases have been devastating plant pathogens to crops. However, there are few efficient agents to control them. Thus, it is crucial to find novel agents to protect crops from pathogenic bacteria. Here, we designed… read more here.
Keywords: triazole moiety; derivatives containing; antibacterial activity; activity ... See more keywords
Design and antifungal evaluation of novel indole derivatives containing benzothiazole and piperidine moieties.
Sign Up to like & getrecommendations! Published in 2025 at "Pest management science"
DOI: 10.1002/ps.70372
Abstract: Twenty-two indole derivatives incorporating benzothiazole and piperidine moieties were synthesized and evaluated for in vitro antifungal activity against eight phytopathogenic fungi. Most compounds exhibited significant antifungal activity, with compound H12 showing the most pronounced inhibition… read more here.
Keywords: benzothiazole piperidine; piperidine moieties; antifungal evaluation; design antifungal ... See more keywords
Chemistry, Applications, and Synthesis Methods of Indole Derivatives: A Comprehensive Review.
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DOI: 10.1002/tcr.202500121
Abstract: Indole and its derivatives represent a crucial class of heterocyclic compounds with broad applications in pharmaceuticals, agrochemicals, and materials science. The indole core is a fundamental structural motif in numerous biologically active natural products, including… read more here.
Keywords: chemistry; review; chemistry applications; synthesis methods ... See more keywords
Design, synthesis and antiviral activity of indole derivatives containing quinoline moiety
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Diversity"
DOI: 10.1007/s11030-024-10894-w
Abstract: A series of indole derivatives containing quinoline structures were designed and synthesized. The synthesized compounds were characterized by NMR and HRMS. And W14 was performed by single crystal X-ray diffraction experiments. The antiviral activity studies… read more here.
Keywords: derivatives containing; antiviral activity; activity; containing quinoline ... See more keywords
Design, synthesis, in-vitro evaluation and molecular docking studies of novel indole derivatives as inhibitors of SIRT1 and SIRT2.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103281
Abstract: Sirtuins (SIRTs), class III HDAC (Histone deacetylase) family proteins, are associated with cancer, diabetes, and other age-related disorders. SIRT1 and SIRT2 are established therapeutic drug targets by regulating its function either by activators or inhibitors.… read more here.
Keywords: sirt1 sirt2; design synthesis; sirt2; inhibitors sirt1 ... See more keywords
Effects of different factors on photodefluorination of perfluorinated compounds by hydrated electrons in organo-montmorillonite system.
Sign Up to like & getrecommendations! Published in 2018 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2017.10.074
Abstract: Perfluorinated compounds (PFCs) are considered as the most recalcitrant organic contaminants. Our previous research has shown that PFCs can be completely defluorinated in the UV/organoclay/3-indole acetic acid system, however, the factors that could affect the… read more here.
Keywords: degradation; system; perfluorinated compounds; indole derivatives ... See more keywords
Synthesis and in vitro anti-proliferative capabilities of steroidal thiazole and indole derivatives
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Saudi Chemical Society"
DOI: 10.1016/j.jscs.2019.05.001
Abstract: Abstract Derivatives (1–15) of steroidal and indole class were synthesized using different strategies. These compounds were characterized by 1H NMR spectroscopy and EI-MS, respectively. The synthetic derivatives were examined for their cytotoxic effects on human… read more here.
Keywords: thiazole indole; proliferative capabilities; indole derivatives; vitro anti ... See more keywords
Quantum chemical exploration on the inhibition performance of indole and some of its derivatives against copper corrosion
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2021.117136
Abstract: Abstract The inhibitory behavior of indole and some of its derivatives and their conformers against copper corrosion was studied by density functional theory (DFT) and molecular dynamics simulations. The calculated reactivity parameters based on the… read more here.
Keywords: copper corrosion; indole derivatives; quantum chemical; chemical exploration ... See more keywords
Synthesis, molecular structure, DFT studies and antimicrobial activities of some novel 3-(1-(3,4-dimethoxyphenethyl)-4,5-diphenyl-1H-imidazol-2-yl)-1H-indole derivatives and its molecular docking studies
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2016.08.021
Abstract: A new series of 3-(1-(3,4-dimethoxyphenethyl)-4,5-diphenyl-1H-imidazol-2-yl)-1H-indole derivatives (5a-5j) are conveniently synthesized and characterized by IR, 1H NMR and 13C NMR spectral techniques. The compound 5f was also confirmed by single crystal XRD analysis and optimized bond… read more here.
Keywords: dimethoxyphenethyl diphenyl; diphenyl imidazol; docking studies; indole derivatives ... See more keywords
Organocatalytic Atroposelective Synthesis of Indole Derivatives Bearing Axial Chirality: Strategies and Applications.
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DOI: 10.1021/acs.accounts.2c00465
Abstract: ConspectusCatalytic atroposelective syntheses of axially chiral compounds have stimulated extensive interest in multiple communities, such as synthetic chemistry, biochemistry, and materials science, because of the intriguing characteristics of atropisomerism. In particular, atropisomeric indole derivatives, which… read more here.
Keywords: chemistry; indole derivatives; indole; axial chirality ... See more keywords
Synthesis, Antibacterial Activity, and Mechanisms of Novel Indole Derivatives Containing Pyridinium Moieties.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c04213
Abstract: The development of effective antibacterial agents equipped with novel action modes and unique skeletons starting from natural compounds serves as an important strategy in the modern pesticide industry. Disclosed here are a series of novel… read more here.
Keywords: antibacterial activity; novel indole; indole derivatives; derivatives containing ... See more keywords