Design, synthesis, in-vitro evaluation and molecular docking studies of novel indole derivatives as inhibitors of SIRT1 and SIRT2.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103281
Abstract: Sirtuins (SIRTs), class III HDAC (Histone deacetylase) family proteins, are associated with cancer, diabetes, and other age-related disorders. SIRT1 and SIRT2 are established therapeutic drug targets by regulating its function either by activators or inhibitors.… read more here.
Keywords: sirt1 sirt2; design synthesis; sirt2; inhibitors sirt1 ... See more keywords
Effects of different factors on photodefluorination of perfluorinated compounds by hydrated electrons in organo-montmorillonite system.
Sign Up to like & getrecommendations! Published in 2018 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2017.10.074
Abstract: Perfluorinated compounds (PFCs) are considered as the most recalcitrant organic contaminants. Our previous research has shown that PFCs can be completely defluorinated in the UV/organoclay/3-indole acetic acid system, however, the factors that could affect the… read more here.
Keywords: degradation; system; perfluorinated compounds; indole derivatives ... See more keywords
Synthesis and in vitro anti-proliferative capabilities of steroidal thiazole and indole derivatives
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Saudi Chemical Society"
DOI: 10.1016/j.jscs.2019.05.001
Abstract: Abstract Derivatives (1–15) of steroidal and indole class were synthesized using different strategies. These compounds were characterized by 1H NMR spectroscopy and EI-MS, respectively. The synthetic derivatives were examined for their cytotoxic effects on human… read more here.
Keywords: thiazole indole; proliferative capabilities; indole derivatives; vitro anti ... See more keywords
Quantum chemical exploration on the inhibition performance of indole and some of its derivatives against copper corrosion
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2021.117136
Abstract: Abstract The inhibitory behavior of indole and some of its derivatives and their conformers against copper corrosion was studied by density functional theory (DFT) and molecular dynamics simulations. The calculated reactivity parameters based on the… read more here.
Keywords: copper corrosion; indole derivatives; quantum chemical; chemical exploration ... See more keywords
Synthesis, molecular structure, DFT studies and antimicrobial activities of some novel 3-(1-(3,4-dimethoxyphenethyl)-4,5-diphenyl-1H-imidazol-2-yl)-1H-indole derivatives and its molecular docking studies
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2016.08.021
Abstract: A new series of 3-(1-(3,4-dimethoxyphenethyl)-4,5-diphenyl-1H-imidazol-2-yl)-1H-indole derivatives (5a-5j) are conveniently synthesized and characterized by IR, 1H NMR and 13C NMR spectral techniques. The compound 5f was also confirmed by single crystal XRD analysis and optimized bond… read more here.
Keywords: dimethoxyphenethyl diphenyl; diphenyl imidazol; docking studies; indole derivatives ... See more keywords
Organocatalytic Atroposelective Synthesis of Indole Derivatives Bearing Axial Chirality: Strategies and Applications.
Sign Up to like & getrecommendations! Published in 2022 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.2c00465
Abstract: ConspectusCatalytic atroposelective syntheses of axially chiral compounds have stimulated extensive interest in multiple communities, such as synthetic chemistry, biochemistry, and materials science, because of the intriguing characteristics of atropisomerism. In particular, atropisomeric indole derivatives, which… read more here.
Keywords: chemistry; indole derivatives; indole; axial chirality ... See more keywords
Synthesis, Antibacterial Activity, and Mechanisms of Novel Indole Derivatives Containing Pyridinium Moieties.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c04213
Abstract: The development of effective antibacterial agents equipped with novel action modes and unique skeletons starting from natural compounds serves as an important strategy in the modern pesticide industry. Disclosed here are a series of novel… read more here.
Keywords: antibacterial activity; novel indole; indole derivatives; derivatives containing ... See more keywords
Design, Synthesis, and Biological Evaluation of Novel Pyrimido[4,5-b]indole Derivatives Against Gram-Negative Multidrug-Resistant Pathogens.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00621
Abstract: Due to the poor permeability across Gram-negative bacterial membranes and the troublesome bacterial efflux mechanism, only a few GyrB/ParE inhibitors with potent activity against Gram-negative pathogens have been reported. Among them, pyrimido[4,5-b]indole derivatives represented by… read more here.
Keywords: gram negative; novel pyrimido; indole derivatives; multidrug resistant ... See more keywords
Discovery of Indole Derivatives as Novel and Potent Dengue Virus Inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00913
Abstract: 3-Acyl-indole derivative 1 was identified as a novel dengue virus (DENV) inhibitor from a DENV serotype 2 (DENV-2) phenotypic antiviral screen. Extensive SAR studies led to the discovery of new derivatives with improved DENV-2 potency… read more here.
Keywords: dengue virus; denv; indole derivatives; discovery indole ... See more keywords
Asymmetric Dearomatizing Fluoroamidation of Indole Derivatives with Dianionic Phase-Transfer Catalyst.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c02026
Abstract: Asymmetric dearomatizing fluorocyclization of indole derivatives was investigated using a dicarboxylate phase-transfer catalyst. This reaction proceeds under mild reaction conditions to provide fluoropyrroloindoline derivatives in a highly enantioselective manner. Various substitution patterns on the indole… read more here.
Keywords: phase transfer; indole derivatives; transfer catalyst; asymmetric dearomatizing ... See more keywords
Palladium Metallaphotoredox-Catalyzed 2-Arylation of Indole Derivatives.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01674
Abstract: Given that biaryl motifs are found in many useful molecules, including pesticides, pharmaceuticals, functional materials, and polymers, the development of methods for their construction is important. Herein, we report a two-step method for C(sp2)-H/C(sp2)-H cross-coupling… read more here.
Keywords: metallaphotoredox catalyzed; arylation indole; indole derivatives; catalyzed arylation ... See more keywords