Catalytic enantioselective hydrophosphinylation of in situ-generated indole-derived vinylogous imines to access 3-(1-diphenylphosphoryl-arylmethyl)indoles.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc04763b
Abstract: An efficient organocatalyzed enantioselective hydrophosphinylation of indole-derived vinylogous imines generated in situ from sulfonyl indoles has been developed. Using quinine-derived bifunctional thiourea as the catalyst, a wide range of structurally diverse chiral 3-(1-diphenylphosphoryl-arylmethyl)indoles were obtained… read more here.
Keywords: diphenylphosphoryl arylmethyl; derived vinylogous; vinylogous imines; enantioselective hydrophosphinylation ... See more keywords
BIS-INDOLE DERIVED NUCLEAR RECEPTOR 4A1 (NR4A1, Nur77) LIGANDS AS INHIBITORS OF ENDOMETRIOSIS.
Sign Up to like & getrecommendations! Published in 2020 at "Endocrinology"
DOI: 10.1210/endocr/bqaa027
Abstract: Endometriosis is an inflammatory disease that primarily affects women during their reproductive years and since current hormonal therapies are of concern new hormone-independent treatment regimens are needed. The orphan nuclear receptor 4A1 (NR4A1, Nur77) is… read more here.
Keywords: nr4a1 nur77; bis indole; 4a1 nr4a1; receptor 4a1 ... See more keywords