New 1H‐indole‐2,3‐dione 3‐thiosemicarbazones with 3‐sulfamoylphenyl moiety as selective carbonic anhydrase inhibitors
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DOI: 10.1002/ardp.202200023
Abstract: 1‐Methyl/ethyl/benzyl‐5‐(un)substituted 1H‐indole‐2,3‐diones (2, 3, and 4) were synthesized by reaction of 5‐(un)substituted 1H‐indole‐2,3‐diones (1) with methyl iodide, ethyl chloride, and benzyl bromide. (3‐Sulfamoylphenyl)isothiocyanate (6) was obtained by the treatment of 3‐aminobenzenesulfonamide (5) with thiophosgene. Compound… read more here.
Keywords: substituted indole; thiosemicarbazones sulfamoylphenyl; new indole; dione ... See more keywords
Unexpected synthesis of a novel heterocyclic system - (7E,10aE)-2,7-Dimethylfuro[3',4':6,7]cycloocta[1,2,3-cd]indole-8,10(2H,6H)-dione
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DOI: 10.1016/j.tetlet.2017.05.062
Abstract: Abstract The first derivative of a novel heterocyclic system, (7 E ,10a E )-2,7-dimethylfuro[3′,4′:6,7]-cycloocta[1,2,3- cd ]indole-8,10(2 H ,6 H )-dione, was synthesized based on the Stobbe condensation of 3-chloro-1-methylindole-2-carbaldehyde with diethyl isopropylidenesuccinate. Cyclization of the… read more here.
Keywords: cycloocta indole; heterocyclic system; novel heterocyclic; indole dione ... See more keywords
Comprehensive spectroscopic (FT-IR, FT-Raman, 1H and 13C NMR) identification and computational studies on 1-acetyl-1H-indole-2,3-dione
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DOI: 10.1515/chem-2017-0026
Abstract: Abstract Fourier transform infrared (FT-IR) and FT-Raman spectra of 1-acetyl-1H-indole-2,3-dione (N-acetylisatin) were recorded in the solid phase and analyzed. The molecular geometry, vibrational frequencies, infrared intensities, Raman activities and atomic charges were calculated using density… read more here.
Keywords: acetyl indole; raman spectra; comprehensive spectroscopic; indole dione ... See more keywords