Synthesis of Indole‐Fused Chromane‐Based Spirooxindoles via Brønsted Acid‐Catalyzed Regioselective [5+1] Annulation
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202401405
Abstract: A regioselective [5+1] annulation of 2‐(1H‐indol‐2‐yl)phenols with isatins was established by the catalysis of Brønsted acid. Through this strategy, indole‐fused chromane‐based spirooxindoles bearing a quaternary carbon center were synthesized in moderate to good yields (53%… read more here.
Keywords: regioselective annulation; fused chromane; indole fused; chromane based ... See more keywords
Indole-fused spirochromenes as potential anti-tubercular agents: design, synthesis and in vitro evaluation
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Diversity"
DOI: 10.1007/s11030-020-10108-z
Abstract: As part of an ongoing effort to develop new anti-tubercular agents, a series of novel indole-fused spirochromene hybrids (7a–l) were efficiently synthesized in excellent yields by the popular ‘Fisher–Indole synthesis’ approach. The structure elucidation of… read more here.
Keywords: tubercular agents; fused spirochromenes; anti tubercular; synthesis ... See more keywords
Palladium-catalyzed synthesis of indole fused coumarins via cross-dehydrogenative coupling
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2016.12.010
Abstract: Abstract The present method describes a palladium-catalyzed cross-dehydrogenative coupling reaction of coumarin and aniline for the synthesis of indole fused coumarin derivatives. The one-pot method is operationally simple and molecular oxygen is used as sole… read more here.
Keywords: cross dehydrogenative; indole fused; palladium catalyzed; dehydrogenative coupling ... See more keywords
Targeting Parallel Topology of G-Quadruplex Structures by Indole- Fused Quindoline Scaffolds.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00373
Abstract: Preferential stabilization of G-quadruplex (G4) structures using small-molecule ligands has emerged as an effective approach to develop anticancer drugs. Herein, we report the synthesis of three indole-fused quindoline derivatives with varying lengths of side chains… read more here.
Keywords: topology; indole fused; fused quindoline; targeting parallel ... See more keywords
Visible-Light-Promoted Cascade Carboxylation/Arylation of Unactivated Alkenes with CO2 for the Synthesis of Carboxylated Indole-Fused Heterocycles.
Sign Up to like & getrecommendations! Published in 2024 at "Organic letters"
DOI: 10.1021/acs.orglett.4c01967
Abstract: Described here is a visible-light-promoted cascade carboxylation/arylation of indole-tethered unactivated alkenes with CO2 to access various carboxylated indole-fused heterocycles. This reaction is initiated by the addition of a CO2 radical anion to the alkene motif… read more here.
Keywords: light promoted; carboxylated indole; visible light; fused heterocycles ... See more keywords
Enantioselective Synthesis of Indole-Fused Polycycles Bearing Four Consecutive Stereocenters via Rhodium Catalysis.
Sign Up to like & getrecommendations! Published in 2025 at "Organic letters"
DOI: 10.1021/acs.orglett.4c04814
Abstract: Indole-fused polycycles are common in natural products and bioactive molecules, yet their concise and efficient synthesis remains challenging, especially for compounds with multiple stereocenters. Herein, we report the application of a chiral CpxRhIII catalyst in… read more here.
Keywords: four consecutive; synthesis; consecutive stereocenters; indole fused ... See more keywords
Visible-Light-Induced Selenium-Mediated Cascade Cyclization of 2-Isocyanobenzonitriles with Secondary Amines to Access Indole-Fused Polycyclics
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DOI: 10.1039/d5gc01245g
Abstract: The development of green and sustainable synthetic methodologies for constructing indole-fused polycyclic frameworks is of paramount importance in modern chemistry. Herein, we present an efficient and environmentally benign visible-light-induced selenium-mediated... read more here.
Keywords: chemistry; induced selenium; visible light; indole fused ... See more keywords
Easy installation of 1,2,3-triazoles or iodo-1,2,3-triazoles onto indole-fused oxazinones via CuAAC-based MCR in the presence of 18-crown-6
Sign Up to like & getrecommendations! Published in 2019 at "Synthetic Communications"
DOI: 10.1080/00397911.2019.1611857
Abstract: Abstract An efficient protocol was developed to prepare indole-fused oxazinones using silver nitrate. The latter substrates were subjected to multicomponent reactions in the presence of 18-crown-6, which afforded diverse new heterocycles based on an indole-fused… read more here.
Keywords: presence crown; indole; indole fused; fused oxazinones ... See more keywords
An insight into the in vivo antitumor therapeutic potential of indole-(fused) pyri(mi)dine hybrids.
Sign Up to like & getrecommendations! Published in 2025 at "Future medicinal chemistry"
DOI: 10.1080/17568919.2025.2504336
Abstract: Cancer can invade and destroy any part of the body, representing a grand social, public health, and economic challenge. Chemotherapy plays a crucial role in cancer treatment, and in recent decades, hundreds of anticancer chemotherapeutics… read more here.
Keywords: cancer; dine hybrids; pyri dine; fused pyri ... See more keywords