Indole-fused spirochromenes as potential anti-tubercular agents: design, synthesis and in vitro evaluation
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Diversity"
DOI: 10.1007/s11030-020-10108-z
Abstract: As part of an ongoing effort to develop new anti-tubercular agents, a series of novel indole-fused spirochromene hybrids (7a–l) were efficiently synthesized in excellent yields by the popular ‘Fisher–Indole synthesis’ approach. The structure elucidation of… read more here.
Keywords: tubercular agents; fused spirochromenes; anti tubercular; synthesis ... See more keywords
Palladium-catalyzed synthesis of indole fused coumarins via cross-dehydrogenative coupling
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DOI: 10.1016/j.tetlet.2016.12.010
Abstract: Abstract The present method describes a palladium-catalyzed cross-dehydrogenative coupling reaction of coumarin and aniline for the synthesis of indole fused coumarin derivatives. The one-pot method is operationally simple and molecular oxygen is used as sole… read more here.
Keywords: cross dehydrogenative; indole fused; palladium catalyzed; dehydrogenative coupling ... See more keywords
Targeting Parallel Topology of G-Quadruplex Structures by Indole- Fused Quindoline Scaffolds.
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DOI: 10.1021/acs.biochem.2c00373
Abstract: Preferential stabilization of G-quadruplex (G4) structures using small-molecule ligands has emerged as an effective approach to develop anticancer drugs. Herein, we report the synthesis of three indole-fused quindoline derivatives with varying lengths of side chains… read more here.
Keywords: topology; indole fused; fused quindoline; targeting parallel ... See more keywords
Easy installation of 1,2,3-triazoles or iodo-1,2,3-triazoles onto indole-fused oxazinones via CuAAC-based MCR in the presence of 18-crown-6
Sign Up to like & getrecommendations! Published in 2019 at "Synthetic Communications"
DOI: 10.1080/00397911.2019.1611857
Abstract: Abstract An efficient protocol was developed to prepare indole-fused oxazinones using silver nitrate. The latter substrates were subjected to multicomponent reactions in the presence of 18-crown-6, which afforded diverse new heterocycles based on an indole-fused… read more here.
Keywords: presence crown; indole; indole fused; fused oxazinones ... See more keywords