Design, synthesis and biological evaluation of indole-2-one derivatives as potent BRD4 inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112780
Abstract: Bromodomain protein 4 (BRD4) plays a crucial role in transcriptional regulation and is considered to be a viable drug target for cancer treatment. Herein, we designed and synthesized a series of indole-2-one derivatives through scaffold… read more here.
Keywords: design synthesis; compound 12j; one derivatives; indole one ... See more keywords
Synthesis, Characterization, Antibacterial Activity And Molecular Docking Studies Of Novel Nitrogen Based Indole-2-One Schiff’s Bases
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Pharmaceutical Negative Results"
DOI: 10.47750/pnr.2022.13.s08.654
Abstract: Series of some novel nitrogen based Indole-2-one Schiff’s bases (4a-4j) were synthesized by a conventional method via Schiff’s bases mechanism. The Istain Schiff’s bases was made by combining substituted isatin with hydrazine hydrate in ethanol… read more here.
Keywords: schiff bases; based indole; schiff; novel nitrogen ... See more keywords