Gut Metabolite Indole‐3‐Propionic Acid Regulates Macrophage Autophagy Through PPT1 Inhibiting Aging‐Related Myocardial Fibrosis
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202501070
Abstract: Cardiac fibrosis, a key pathological feature of cardiac remodeling, is a major contributor to mortality in older patients with heart failure. The underlying mechanisms are complex, involving alterations in intercellular communication and chronic inflammation. This… read more here.
Keywords: related myocardial; fibrosis; myocardial fibrosis; indole propionic ... See more keywords
Modulation of Host Immunity by Microbiome‐Derived Indole‐3‐Propionic Acid and Other Bacterial Metabolites
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Immunology"
DOI: 10.1002/eji.202451594
Abstract: In recent years, we have witnessed a rapidly growing interest in the intricate communications between intestinal microorganisms and the host immune system. Research on the human microbiome is evolving from merely descriptive and correlative studies… read more here.
Keywords: indole propionic; modulation host; propionic acid; immunity ... See more keywords
Indole-3-propionic acid mitigates chlorpyrifos-mediated neurotoxicity by modulating cholinergic and redox-regulatory systems, inflammatory stress, apoptotic responses and DNA damage in rats.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental toxicology and pharmacology"
DOI: 10.1016/j.etap.2021.103786
Abstract: This study probed the neuroprotective influence of indole-3-propionic acid (IPA) in rats exposed to chlorpyrifos (CPF) alone at 5mg/kg body weight or co-administered with IPA at 12.5 and 25mg/kg for 14 days. Behavioral data indicated… read more here.
Keywords: damage; propionic acid; redox regulatory; inflammatory stress ... See more keywords
Indole-3-propionic Acid Attenuates HI-Related Blood-Brain Barrier Injury in Neonatal Rats by Modulating the PXR Signaling Pathway.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00418
Abstract: The blood-brain barrier (BBB) is an important physiological barrier of the human body contributing to maintaining brain homeostasis and normal function. Hypoxic-ischemic (HI)-related brain injury is one of the main causes of neonatal acute morbidity… read more here.
Keywords: bbb; blood brain; indole propionic; brain barrier ... See more keywords
Indole Propionic Acid Disturbs the Normal Function of Tryptophanyl-tRNA Synthetase in Mycobacterium tuberculosis.
Sign Up to like & getrecommendations! Published in 2024 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.3c00585
Abstract: Tuberculosis (TB) is the leading infectious disease caused by Mycobacterium tuberculosis and the second-most contagious killer after COVID-19. The emergence of drug-resistant TB has caused a great need to identify and develop new anti-TB drugs… read more here.
Keywords: tryptophanyl trna; propionic acid; indole propionic; tuberculosis ... See more keywords
Microbiota-indole-3-propionic acid-heart axis mediates the protection of leflunomide against αPD1-induced cardiotoxicity in mice
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-58107-8
Abstract: Anti-programmed death 1 (αPD1) immune checkpoint blockade is used in combination for cancer treatment but associated with cardiovascular toxicity. Leflunomide (Lef) can suppress the growth of several tumor and mitigate cardiac remodeling in mice. However,… read more here.
Keywords: propionic acid; pd1; indole propionic; induced cardiotoxicity ... See more keywords
Protective effects of indole-3-propionic acid against TCP-induced hearing loss in mice by mitigating oxidative stress and promoting neutrophil recruitment
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-90655-3
Abstract: Sensorineural hearing loss (SNHL) poses a significant global health challenge with substantial socioeconomic and medical implications. The pathophysiology involves excessive reactive oxygen species (ROS) in the cochlea, inflammation, cellular apoptosis, etc. Tryptophan metabolite indole-3-propionic Acid… read more here.
Keywords: mice; propionic acid; loss; indole propionic ... See more keywords
The microbial metabolite indole-3-propionic acid improves glucose metabolism in rats, but does not affect behaviour
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Physiology and Biochemistry"
DOI: 10.1080/13813455.2017.1398262
Abstract: Abstract Context: We have previously shown that an antidepressant-like effect of probiotics in rats was associated with a higher plasma level of the microbial tryptophan metabolite indole-3-propionic acid (IPA). Objective: We therefore wanted to study… read more here.
Keywords: metabolism rats; indole propionic; metabolite indole; glucose metabolism ... See more keywords
Indole-3-propionic acid links gut dysfunction to diabetic retinopathy: a biomarker and novel therapeutic approach
Sign Up to like & getrecommendations! Published in 2025 at "Gut"
DOI: 10.1136/gutjnl-2025-336180
Abstract: Background Both host and microbe metabolism of tryptophan (Trp) is altered in diabetes; however, the molecular mechanisms are incompletely understood. Objective We used strategies to increase either angiotensin converting enzyme-2 (ACE-2) dependent or independent Trp… read more here.
Keywords: propionic acid; indole propionic; trp; diabetic retinopathy ... See more keywords
Indole-3-propionic acid promotes hepatic stellate cells inactivation
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-025-06266-z
Abstract: We have previously reported that the serum levels of gut-derived tryptophan metabolite indole-3-propionic acid (IPA) are lower in individuals with liver fibrosis. Now, we explored the transcriptome and DNA methylome associated with serum IPA levels… read more here.
Keywords: propionic acid; stellate; indole propionic; stellate cells ... See more keywords
The gut metabolite indole-3-propionic acid activates ERK1 to restore social function and hippocampal inhibitory synaptic transmission in a 16p11.2 microdeletion mouse model
Sign Up to like & getrecommendations! Published in 2024 at "Microbiome"
DOI: 10.1186/s40168-024-01755-7
Abstract: Background Microdeletion of the human chromosomal region 16p11.2 (16p11.2 $${}^{+/-}$$ + / - ) is a prevalent genetic factor associated with autism spectrum disorder (ASD) and other neurodevelopmental disorders. However its pathogenic mechanism remains unclear,… read more here.
Keywords: propionic acid; indole propionic; microdeletion; gut ... See more keywords