Indole-3-propionic acid mitigates chlorpyrifos-mediated neurotoxicity by modulating cholinergic and redox-regulatory systems, inflammatory stress, apoptotic responses and DNA damage in rats.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental toxicology and pharmacology"
DOI: 10.1016/j.etap.2021.103786
Abstract: This study probed the neuroprotective influence of indole-3-propionic acid (IPA) in rats exposed to chlorpyrifos (CPF) alone at 5mg/kg body weight or co-administered with IPA at 12.5 and 25mg/kg for 14 days. Behavioral data indicated… read more here.
Keywords: damage; propionic acid; redox regulatory; inflammatory stress ... See more keywords
Indole-3-propionic Acid Attenuates HI-Related Blood-Brain Barrier Injury in Neonatal Rats by Modulating the PXR Signaling Pathway.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00418
Abstract: The blood-brain barrier (BBB) is an important physiological barrier of the human body contributing to maintaining brain homeostasis and normal function. Hypoxic-ischemic (HI)-related brain injury is one of the main causes of neonatal acute morbidity… read more here.
Keywords: bbb; blood brain; indole propionic; brain barrier ... See more keywords
The microbial metabolite indole-3-propionic acid improves glucose metabolism in rats, but does not affect behaviour
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Physiology and Biochemistry"
DOI: 10.1080/13813455.2017.1398262
Abstract: Abstract Context: We have previously shown that an antidepressant-like effect of probiotics in rats was associated with a higher plasma level of the microbial tryptophan metabolite indole-3-propionic acid (IPA). Objective: We therefore wanted to study… read more here.
Keywords: metabolism rats; indole propionic; metabolite indole; glucose metabolism ... See more keywords
Gut-Derived Metabolite Indole-3-Propionic Acid Modulates Mitochondrial Function in Cardiomyocytes and Alters Cardiac Function
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2021.648259
Abstract: Background: The gut microbiome has been linked to the onset of cardiometabolic diseases, in part facilitated through gut microbiota-dependent metabolites such as trimethylamine-N-oxide. However, molecular pathways associated to heart failure mediated by microbial metabolites remain… read more here.
Keywords: mitochondrial function; indole propionic; gut derived; function ... See more keywords
Biological Effects of Indole-3-Propionic Acid, a Gut Microbiota-Derived Metabolite, and Its Precursor Tryptophan in Mammals’ Health and Disease
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031222
Abstract: Actions of symbiotic gut microbiota are in dynamic balance with the host’s organism to maintain homeostasis. Many different factors have an impact on this relationship, including bacterial metabolites. Several substrates for their synthesis have been… read more here.
Keywords: health; gut; gut microbiota; indole propionic ... See more keywords
Extensive Summary of the Important Roles of Indole Propionic Acid, a Gut Microbial Metabolite in Host Health and Disease
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu15010151
Abstract: Increasing evidence suggests that metabolites produced by the gut microbiota play a crucial role in host–microbe interactions. Dietary tryptophan ingested by the host enters the gut, where indole-like metabolites such as indole propionic acid (IPA)… read more here.
Keywords: propionic acid; indole propionic; disease; host health ... See more keywords
Cumulative Protective Effect of Melatonin and Indole-3-Propionic Acid against KIO3—Induced Lipid Peroxidation in Porcine Thyroid
Sign Up to like & getrecommendations! Published in 2021 at "Toxics"
DOI: 10.3390/toxics9050089
Abstract: Iodine deficiency is the main environmental factor leading to thyroid cancer. At the same time iodine excess may also contribute to thyroid cancer. Potassium iodate (KIO3), which is broadly used in salt iodization program, may… read more here.
Keywords: melatonin indole; indole propionic; kio3; melatonin ... See more keywords