Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR) α/γ/δ Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate.
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DOI: 10.1021/acs.jmedchem.7b01285
Abstract: Here, we describe the identification and synthesis of novel indole sulfonamide derivatives that activate the three peroxisome proliferator activated receptor (PPAR) isoforms. Starting with a PPARα activator, compound 4, identified during a high throughput screening… read more here.
Keywords: ppar; peroxisome proliferator; receptor ppar; indole sulfonamide ... See more keywords
Investigations on Anticancer and Antimalarial Activities of Indole-Sulfonamide Derivatives and In Silico Studies
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DOI: 10.1021/acsomega.1c04552
Abstract: A library of 44 indole-sulfonamide derivatives (1–44) were investigated for their cytotoxic activities against four cancer cell lines (i.e., HuCCA-1, HepG2, A549, and MOLT-3) and antimalarial effect. Most of the studied indoles exhibit anticancer activity… read more here.
Keywords: activities indole; antimalarial activities; investigations anticancer; sulfonamide derivatives ... See more keywords