Asymmetric Divergent Total Syntheses of (+)-Decursivine and (+)- Serotobenine via Intramolecular Fischer Indole Synthesis.
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DOI: 10.1021/acs.orglett.2c00848
Abstract: A new asymmetric synthetic route to (+)-decursivine and (+)-serotobenine is formulated. The key developments are the de novo construction of the crucial eight-membered 3,4-fused tricyclic indole ring engaged by the intramolecular Fischer indole synthesis and… read more here.
Keywords: indole synthesis; intramolecular fischer; asymmetric divergent; divergent total ... See more keywords
A Halogen-Atom Transfer (XAT)-Based Approach to Indole Synthesis Using Aryl Diazonium Salts and Alkyl Iodides
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DOI: 10.1021/acs.orglett.2c02840
Abstract: Indoles are among the most important N-heterocycles in pharmaceuticals. Here, we present an alternative to the classic Fischer indole synthesis based on the radical coupling between aryl diazoniums and alkyl iodides. This iron-mediated strategy features… read more here.
Keywords: indole synthesis; halogen atom; alkyl iodides; atom transfer ... See more keywords
Enantioselective Copper-Catalyzed Fukuyama Indole Synthesis from 2-Vinylphenyl Isocyanides.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c01667
Abstract: Enantioenriched chiral indoles are of high interest for the pharmaceutical and agrochemical industries. Herein, we present an asymmetric Fukuyama indole synthesis through a mild and efficient radical cascade reaction to access 2-fluoroalkylated 3-(α-cyanobenzylated) indoles by… read more here.
Keywords: indole synthesis; fukuyama indole; synthesis; enantioselective copper ... See more keywords
Step and redox efficient nitroarene to indole synthesis.
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DOI: 10.1039/d0cc03258a
Abstract: Step and redox efficiencies are a rising priority in synthetic method development, in order to make synthetic processes more sustainable and more affordable. Herein, a step and redox efficient nitroarene to indole synthesis is developed,… read more here.
Keywords: nitroarene indole; indole synthesis; redox efficient; step redox ... See more keywords
Photoredox Fischer Indole Synthesis
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DOI: 10.1055/s-0037-1611535
Abstract: Visible light photoredox conditions were applied to the traditional Fischer indole synthesis. N,N-Diarylhydrazones were efficiently converted into the corresponding indoles even at 30 °C by treatment with bromotrichloromethane in the presence of Ru(bpy)3Cl2·6H2O as the photocatalyst.… read more here.
Keywords: synthesis; synthesis photoredox; fischer indole; indole synthesis ... See more keywords