A Series of 2‐((1‐Phenyl‐1H‐imidazol‐5‐yl)methyl)‐1H‐indoles as Indoleamine 2,3‐Dioxygenase 1 (IDO1) Inhibitors
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DOI: 10.1002/cmdc.202100107
Abstract: Indoleamine 2,3‐dioxygenase 1 (IDO1) is a promising therapeutic target in cancer immunotherapy and neurological disease. Thus, searching for highly active inhibitors for use in human cancers is now a focus of widespread research and development… read more here.
Keywords: brain penetrant; dioxygenase ido1; ido1 inhibitors; indoleamine dioxygenase ... See more keywords
Indoleamine 2,3-dioxygenase expression in the prognosis of the localized prostate cancer
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DOI: 10.1007/s11255-020-02414-0
Abstract: Background Indoleamine 2,3-dioxygenase (IDO1) is an enzyme that acts as an immunomodulatory molecule. It is found in several types of cancer where it seems to be associated with tumor escape due to its immunosuppressive mechanisms.… read more here.
Keywords: prostate; recurrence; ido1 expression; expression ... See more keywords
UV Resonance Raman Characterization of a Substrate Bound to Human Indoleamine 2,3-Dioxygenase 1.
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DOI: 10.1016/j.bpj.2019.07.017
Abstract: Human indoleamine 2,3-dioxygenase 1 (IDO) is a heme enzyme that catalyzes the first reaction of the main metabolic pathway of L-tryptophan (Trp) to produce N-formylkynurenin. The reaction involves cleavage of the C2=C3 bond in the… read more here.
Keywords: human indoleamine; trp; reaction; indoleamine dioxygenase ... See more keywords
Therapeutic antibody targeting of indoleamine-2,3-dioxygenase (IDO2) inhibits autoimmune arthritis.
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DOI: 10.1016/j.clim.2017.01.016
Abstract: Rheumatoid arthritis (RA) is a debilitating inflammatory autoimmune disease with no known cure. Recently, we identified the immunomodulatory enzyme indoleamine-2,3-dioxygenase 2 (IDO2) as an essential mediator of autoreactive B and T cell responses driving RA.… read more here.
Keywords: antibody; therapeutic antibody; dioxygenase ido2; indoleamine dioxygenase ... See more keywords
The rationale of indoleamine 2,3-dioxygenase inhibition for cancer therapy.
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DOI: 10.1016/j.ejca.2017.01.011
Abstract: Indoleamine 2,3-dioxygenase (IDO, also referred to as IDO1) has been demonstrated to be a normal endogenous mechanism of acquired peripheral immune tolerance in vivo. In the field of oncology, IDO expression and/or activity has been observed… read more here.
Keywords: rationale indoleamine; inhibition; dioxygenase inhibition; cancer ... See more keywords
Indoleamine 2,3-dioxygenase 1 and programmed cell death-ligand 1 co-expression correlates with aggressive features in lung adenocarcinoma.
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DOI: 10.1016/j.ejca.2018.06.020
Abstract: BACKGROUND Indoleamine 2,3-dioxygenase 1 (IDO1) is an immunosuppressive effector, and its expression is associated with prognosis in several cancer types. Here, we investigated the relationship between IDO1 expression in lung adenocarcinoma and patient prognosis and… read more here.
Keywords: lung adenocarcinoma; indoleamine dioxygenase; programmed cell; expression ... See more keywords
Discovery and evaluation of inhibitors to the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1): Probing the active site-inhibitor interactions.
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DOI: 10.1016/j.ejmech.2016.12.029
Abstract: High expression of the immunosuppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1) for a broad range of malignancies is associated with poor patient prognosis, and the enzyme is a validated target for cancer intervention. To identify novel… read more here.
Keywords: ido1; enzyme indoleamine; dioxygenase ido1; ido1 inhibitors ... See more keywords
Design, synthesis and biological evaluation of a novel library of antimitotic C2‐aroyl/arylimino tryptamine derivatives that are also potent inhibitors of indoleamine‐2, 3‐dioxygenase (IDO)
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DOI: 10.1016/j.ejps.2018.08.033
Abstract: ABSTRACT A novel library of C2‐substituted tryptamines (based on diverse C2‐aroyl/arylimino indoles and indole‐diketopiperazine hybrids) possessing antimitotic properties were designed, synthesized and screened for their inhibitory activity against tubulin polymerization, and against proliferation of A549… read more here.
Keywords: aroyl arylimino; hela; cancer; indoleamine dioxygenase ... See more keywords
An indoleamine 2, 3‐dioxygenase siRNA nanoparticle‐coated and Trp2‐displayed recombinant yeast vaccine inhibits melanoma tumor growth in mice
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DOI: 10.1016/j.jconrel.2018.01.013
Abstract: &NA; Therapeutic vaccine is a promising approach in cancer therapy. But tumor‐associated antigen peptides have weak immunogenicity and cancer patients are often characterized by immunosuppression and tolerance, leading to less efficiency of immunotherapy. We here… read more here.
Keywords: trp2 displayed; nanoparticle coated; sirna nanoparticle; vaccine ... See more keywords
Indoleamine 2,3-dioxygenase and trophoblast invasion in caesarean scar pregnancy: Implications for the aetiopathogenesis of placenta accreta spectrum.
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DOI: 10.1016/j.jri.2020.103099
Abstract: Immunohistochemical localisation of indoleamine 2,3-dioxygenase was studied in order to better understand the pathophysiology of placenta accreta spectrum. In the decidua staining for indoleamine 2,3-dioxygenase was found in the glandular epithelium with some additional positive… read more here.
Keywords: accreta spectrum; trophoblast invasion; dioxygenase; indoleamine dioxygenase ... See more keywords
Characterization of the temporal, cell-specific and interferon-inducible patterns of indoleamine 2,3 dioxygenase 1 (IDO1) expression in the human placenta across gestation.
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DOI: 10.1016/j.placenta.2021.09.008
Abstract: INTRODUCTION The human placenta performs multiple functions necessary for successful pregnancy, but the metabolic pathways and molecular mechanisms responsible for regulating placental development and functions remain incompletely understood. Catabolism of the essential amino acid tryptophan… read more here.
Keywords: expression human; human placenta; ido1 expression; expression ... See more keywords