Alkyne Hydroheteroarylation: Enantioselective Coupling of Indoles and Alkynes via Rh-Hydride Catalysis.
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DOI: 10.1021/jacs.7b05893
Abstract: We report an enantioselective coupling between alkynes and indoles. A Rh-hydride catalyst isomerizes alkynes to generate a metal-allyl species that can be trapped with both aromatic and heteroaromatic nucleophiles. read more here.
Keywords: enantioselective coupling; indoles alkynes; hydroheteroarylation enantioselective; coupling indoles ... See more keywords