Synthesis of C7-Functionalized Indoles through an Aromaticity Destruction-Reconstruction Process.
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DOI: 10.1021/acs.orglett.2c00733
Abstract: A process for the synthesis of C7-functionalized indoles using para-substituted 2-alkynylanilines as starting materials was reported. The process involves a dearomatization, an 1,2-addition by organic lithium or Grignard reagents, an aromatization-driven allylic rearrangement, and a… read more here.
Keywords: synthesis functionalized; functionalized indoles; indoles aromaticity; process synthesis ... See more keywords