Perfluoropyridylation of indoles via reaction of perfluorinated pyridines with indole compounds
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-020-01858-6
Abstract: Abstract The reaction of perfluoropyridines with indoles and bis(indolyl)methanes (BIMs) was investigated. The aromatic nucleophilic substitution of pentafluoropyridine with indoles occurs at the 4-position of pyridine ring by nitrogen site of indolyl anion, while reaction… read more here.
Keywords: via reaction; perfluoropyridylation indoles; reaction perfluorinated; indoles via ... See more keywords
Synthesis of 1,4-dihydropyrazolo[4,3-b]indoles via intramolecular C(sp2)-N bond formation involving nitrene insertion, DFT study and their anticancer assessment.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105114
Abstract: We herein report a new synthetic route for a series of unreported 1,4-dihydropyrazolo[4,3-b]indoles (6-8) via deoxygenation of o-nitrophenyl-substituted N-aryl pyrazoles and subsequent intramolecular (sp2)-N bond formation under microwave irradiation expedite modified Cadogan condition. This method… read more here.
Keywords: bond formation; intramolecular sp2; indoles via; dft study ... See more keywords
Cobalt-Catalyzed Dearomatization of Indoles via Transfer Hydrogenation To Afford Polycyclic Indolines.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c00354
Abstract: A cobalt-catalyzed dearomatization of indoles via transfer hydrogenation with HBpin and H2O has been developed. This reaction offered a straightforward platform to access hexahydropyrido[1,2-a]indoles in high regio- and chemoselectivity. A preliminary reaction mechanism was proposed… read more here.
Keywords: catalyzed dearomatization; via transfer; transfer hydrogenation; cobalt catalyzed ... See more keywords
Synthesis of 2-BMIDA Indoles via Heteroannulation: Applications in Drug Scaffold and Natural Product Synthesis
Sign Up to like & getrecommendations! Published in 2022 at "Organic Letters"
DOI: 10.1021/acs.orglett.2c00959
Abstract: A Pd-catalyzed heteroannulation approach for the synthesis of C2 borylated indoles is reported. The process allows access to highly functionalized 2-borylated indole scaffolds with complete control of regioselectivity. The utility of the process is demonstrated… read more here.
Keywords: synthesis bmida; synthesis; bmida indoles; heteroannulation ... See more keywords
Modular Divergent Synthesis of Functionalized Indoles via TFA-Promoted Amino-Claisen Rearrangement at Room Temperature.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00764
Abstract: A conceptually novel approach for the modular and divergent synthesis of highly functionalized indoles via trifluoroacetic acid-promoted amino-Claisen rearrangement is reported. This metal-free protocol could be performed at room temperature with wide functional group tolerance.… read more here.
Keywords: amino claisen; functionalized indoles; divergent synthesis; indoles via ... See more keywords
Direct Access to Functionalized Indoles via Single Electron Oxidation Induced Coupling of Diarylamines with 1,3-Dicarbonyl Compounds.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b02349
Abstract: Under aerobic copper catalysis, an unprecedented direct synthesis of functionalized indoles via single electron oxidation induced coupling of diarylamines with 1,3-dicarbonyl compounds is presented. The protocol proceeds with good functional group and substrate compatibility, the… read more here.
Keywords: functionalized indoles; single electron; oxidation induced; indoles via ... See more keywords
Synthesis of 4,7-Difunctionalized Indoles via Imino Exchange and Sulfinyl Migration.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.9b04257
Abstract: A process that rapidly assembles 4,7-difunctionalized indoles from 2-alkynycyclohexadienimines, sulfinamides, and nucleophiles (amines or alcohols) was developed. The process involves imino exchange, cascade cyclization/1,4-nucleophilic addition/aromatization, and 1,3-migration of the sulfinyl group. The 7-sulfinyl group is… read more here.
Keywords: imino exchange; difunctionalized indoles; synthesis difunctionalized; migration ... See more keywords
Synthesis of 2,3-disubstituted indoles via a tandem reaction
Sign Up to like & getrecommendations! Published in 2020 at "Organic chemistry frontiers"
DOI: 10.1039/d0qo00765j
Abstract: A strategy for the synthesis of 2,3-disubstituted indoles from 2-allyl-2-(2-nitrophenyl)cyclohexane-1,3-dione has been developed. A wide array of 2,3-disubstituted indoles were accessed in modest to good yields via a tandem reduction/condensation/fragmentation/cyclization sequence. The utility of this… read more here.
Keywords: via tandem; tandem reaction; indoles via; synthesis disubstituted ... See more keywords
Synthesis of Piperidinone and Azepanone Fused Indoles via a Wagner–Meerwein Type 1,2-Amide Migration of 2-Spiropseudoindoxyls
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DOI: 10.1055/s-0036-1588138
Abstract: Spiropseudoindoxyls were synthesized by using a gold(III)-catalyzed intramolecular nitroalkyne redox–dipolar cycloaddition cascade. These compounds were then transformed into novel piperidinone and azepanone fused indoles via a straightforward hydrogenation. The reaction mechanism of this ring expansion… read more here.
Keywords: wagner meerwein; piperidinone azepanone; meerwein type; indoles via ... See more keywords
Iron-Promoted Construction of Indoles via Intramolecular Oxidative C–N Coupling of 2-Alkenylanilines Using Persulfate
Sign Up to like & getrecommendations! Published in 2019 at "Synthesis"
DOI: 10.1055/s-0037-1611521
Abstract: Indole scaffold synthesis relies primarily on oxidative C–H amination of N-protected alkenylanilines for C–N intramolecular cyclization reactions. Herein, for the first time, without N-protection, various readily prepared 2-alkenylanilines were transformed into the desired indole products… read more here.
Keywords: iron promoted; construction indoles; via intramolecular; indoles via ... See more keywords
Synthesis of 2-Substitued Indoles via Pd-Catalysed Cyclization in an Aqueous Micellar Medium
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26133917
Abstract: The synthesis of 2-substituted indoles starting from the corresponding unprotected 2-alkynylanilines was made possible in 3% TPGS-750-M water using Pd(OAc)2 alone as the catalyst. The reaction was sensitive to the heating mode respect to the… read more here.
Keywords: catalysed cyclization; synthesis substitued; via catalysed; indoles via ... See more keywords