Asymmetric Synthesis of Quaternary ‐Perfluorophenyl‐‐Amino‐Indolin‐2‐ones
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201601645
Abstract: Abstract. Reported herein is a design and synthesis of N-tert-butylsulfinyl-(perfluoro)benzaldimine, and study of its reactivity and stereocontrolling properties in the Mannich addition reactions with in situ generated indolinone derived tertiary enolates. The corresponding products, quaternary… read more here.
Keywords: indolin ones; amino indolin; quaternary perfluorophenyl; perfluorophenyl amino ... See more keywords
HFIP-promoted catalyst-free cascade reactions for the synthesis of biologically relevant 3,3-di(indolyl)indolin-2-ones from indoles and isatins
Sign Up to like & getrecommendations! Published in 2020 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2020.03.025
Abstract: Abstract The first HFIP-promoted catalyst-free cascade reactions for the synthesis of biologically relevant 3,3-di(indolyl)indolin-2-ones (27 examples, up to 98% yield) from readily available indoles and isatin derivatives are described. This protocol shows well tolerance of… read more here.
Keywords: indolin ones; hfip promoted; indolyl indolin; catalyst free ... See more keywords
Chemoselective N-H or C-2 Arylation of Indole-2-carboxamides: Controllable Synthesis of Indolo[1,2- a]quinoxalin-6-ones and 2,3'-Spirobi[indolin]-2'-ones.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b02197
Abstract: Novel methods involving the chemoselective N-H or C-2 arylation for the synthesis of indolo[1,2- a]quinoxalin-6-ones and 2,3'-spirobi[indolin]-2'-ones starting from indole-2-carboxamides were developed. When reactions were carried out using ZnI2 as catalyst and Ag2CO3 as oxidant,… read more here.
Keywords: quinoxalin ones; indolo quinoxalin; spirobi indolin; indolin ones ... See more keywords
Discovery and Anticancer Activity of Novel 1,3,4-Thiadiazole- and Aziridine-Based Indolin-2-ones via In Silico Design Followed by Supramolecular Green Synthesis
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DOI: 10.1021/acsomega.2c01198
Abstract: Three crucial anticancer scaffolds, namely indolin-2-one, 1,3,4-thiadiazole, and aziridine, are explored to synthesize virtually screened target molecules based on the c-KIT kinase protein. The stem cell factor receptor c-KIT was selected as target because most… read more here.
Keywords: thiadiazole; cell; indolin ones; aziridine ... See more keywords
Synthesis of tetracyclic indolin-3-ones through Pd-catalyzed intramolecular deacetylative dearomatization of 3-acetoxy-indoles
Sign Up to like & getrecommendations! Published in 2019 at "RSC Advances"
DOI: 10.1039/c9ra02569c
Abstract: An efficient palladium-catalyzed intramolecular deacetylative dearomatization reaction of 3-acetoxyindoles is disclosed, affording tetracyclic indolin-3-ones bearing C2-quaternary stereocenters in good yields. read more here.
Keywords: intramolecular deacetylative; tetracyclic indolin; indolin ones; catalyzed intramolecular ... See more keywords
E–Z isomerization of 3-benzylidene-indolin-2-ones using a microfluidic photo-reactor
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DOI: 10.1039/d0ra05288d
Abstract: Here, we report controlled E–Z isomeric motion of the functionalized 3-benzylidene-indolin-2-ones under various solvents, temperature, light sources, and most importantly effective enhancement of light irradiance in microfluidic photoreactor conditions. Stabilization of the E–Z isomeric motion… read more here.
Keywords: indolin ones; photo; isomerization benzylidene; using microfluidic ... See more keywords
Novel [(3-indolylmethylene)hydrazono]indolin-2-ones as apoptotic anti-proliferative agents: design, synthesis and in vitro biological evaluation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2017.1421181
Abstract: Abstract On account of their significance as apoptosis inducing agents, merging indole and 3-hydrazinoindolin-2-one scaffolds is a logic tactic for designing pro-apoptotic agents. Consequently, 27 hybrids (6a–r, 9a–f and 11a–c) were synthesised and evaluated for… read more here.
Keywords: indolin ones; apoptotic anti; indolylmethylene hydrazono; novel indolylmethylene ... See more keywords
An iodine-promoted one-pot and metal-free access to indolin-2-ones
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Chemical Research"
DOI: 10.1177/1747519819875862
Abstract: A new method for the synthesis of indolin-2-ones has been realized by an I2-promoted oxidative reaction from 1,2,3,3-tetramethyl-3H-indolium iodides. This transformation proceeded smoothly under metal-free and peroxide-free conditions in a cascade manner. read more here.
Keywords: indolin ones; iodine promoted; promoted one; one pot ... See more keywords
Efficient Synthesis of 2,3′-Spirobi (Indolin)-2′-Ones and Preliminary Evaluation of Their Damage to Mitochondria in HeLa Cells
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.821518
Abstract: A novel formal (4 + 1) annulation between N-(o-chloromethyl)aryl amides and 3-chlorooxindoles through in situ generated aza-ortho-QMs with 3-chlorooxindoles is reported for the synthesis of a series of 2,3′-spirobi (indolin)-2′-ones in high yields. Under structured… read more here.
Keywords: spirobi indolin; synthesis spirobi; ones preliminary; efficient synthesis ... See more keywords
Effect of a =X-NH-Fragment, (X = C, N), on Z/E Isomerization and ON/OFF Functionality of Isatin Arylhydrazones, ((Arylamino)Methylene)Indolin-2-Ones and Their Anions
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25133082
Abstract: The subject of this work was the study of thermally and photochemically stimulated Z ↔ E isomerization and hydrazo ↔ azo tautomerism of Z- and E-isomers of isatin arylhydrazones and ((arylamino)methylene)indolin-2-ones and their anions. Using… read more here.
Keywords: indolin ones; methylene indolin; isatin arylhydrazones; arylhydrazones arylamino ... See more keywords