Discovery of indoline derivatives that inhibit esophageal squamous cell carcinoma growth by Noxa mediated apoptosis.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103190
Abstract: A series of novel indoline derivatives were synthesized and evaluated for antiproliferative activity against four selected cancer cell lines (Hela, A549, HepG2 and KYSE30). Among them, compound 20 displayed the potent inhibition activity against esophageal… read more here.
Keywords: esophageal squamous; apoptosis; cell carcinoma; squamous cell ... See more keywords
Asymmetric Synthesis of Spirofuro[2,3-b]azepine-5,3’-indoline Derivatives via Cycloisomerization/[4+3] Annulation Process under Au/N-Heterocyclic Carbene Relay Catalysis
Sign Up to like & getrecommendations! Published in 2023 at "Organic Chemistry Frontiers"
DOI: 10.1039/d3qo00539a
Abstract: A variety of enantioenriched spirofuro[2,3-b]azepine-5,3’-indoline derivatives (dr > 20:1, up to 96% ee) were facilely synthesized through cycloisomerization/asymmetric formal [4+3] cycloaddition reactions of enyne-amides with isatin-derived enals under gold(I)/chiral N-heterocyclic... read more here.
Keywords: spirofuro azepine; cycloisomerization; azepine indoline; indoline derivatives ... See more keywords