Insight on a new indolinone derivative as an orally bioavailable lead compound against renal cell carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.104985
Abstract: A series of novel 3-indolinone-thiazolidinones and oxazolidinones 4a-k was synthesized via molecular hybridization approach and sequentially evaluated to explore its cytotoxic activity. The cytotoxicity screening pointed toward the N-cyclohexyl thiazolidinone derivative 4f that revealed promising… read more here.
Keywords: renal cell; cell carcinoma; compound renal; indolinone ... See more keywords
5,5- and 5,6-Membered Spirocyclic Indolinone Hit-Finding Libraries.
Sign Up to like & getrecommendations! Published in 2019 at "ACS combinatorial science"
DOI: 10.1021/acscombsci.9b00057
Abstract: The production of two libraries based on spirocyclic indolinones is described. These libraries were selected from numerous spirocyclic indolinone scaffolds with a library evaluation procedure used routinely at Novartis, based on computed physicochemical properties and… read more here.
Keywords: indolinone; finding libraries; membered spirocyclic; hit finding ... See more keywords