The synthesis of perfluoroalkylated indolizines via tandem cyclization/aromatization
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Fluorine Chemistry"
DOI: 10.1016/j.jfluchem.2021.109900
Abstract: Abstract The incorporation of a perfluoroalkyl group into heterocycles has received increasing attention. Herein we describe the synthesis of perfluoroalkylated indolizines via a tandem cyclization/aromatization process under mild conditions. In contrast to previous synthetic methods,… read more here.
Keywords: tandem cyclization; cyclization aromatization; indolizines via; via tandem ... See more keywords
Synthesis of Indolizines via Reaction of 2-Substitued Azaarenes with Enals by an Amine-NHC Relay Catalysis.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b00566
Abstract: A metal-free catalytic strategy for the facile synthesis of biologically relevant molecular architectures indolizines and imidazopyridines has been developed. The process is promoted by amine and N-heterocyclic carbene (NHC) relay catalysis via Michael addition-[3 +… read more here.
Keywords: nhc relay; synthesis indolizines; indolizines via; relay catalysis ... See more keywords
C3 Functionalization of Indolizines via HFIP-Promoted Friedel–Crafts Reactions with (Hetero)arylglyoxals
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.3c00236
Abstract: A highly efficient Friedel–Crafts type hydroxyalkylation at the C3 position of indolizines with (hetero)arylglyoxals has been achieved by the action of hexafluoroisopropanol (HFIP) under mild reaction conditions, leading to direct access to a variety of… read more here.
Keywords: indolizines via; friedel crafts; via hfip; hetero arylglyoxals ... See more keywords