Synthesis, cytotoxicity and structure-activity relationship of indolizinoquinolinedione derivatives as DNA topoisomerase IB catalytic inhibitors.
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DOI: 10.1016/j.ejmech.2018.04.040
Abstract: Our previous studies reveal that indolizinoquinolinedione scaffold is a base to develop novel DNA topoisomerase IB (TOP1) catalytic inhibitors. In this work, twenty-three novel indolizinoquinolinedione derivatives were synthesized. TOP1-mediated relaxation, nicking and unwinding assays revealed… read more here.
Keywords: dna topoisomerase; indolizinoquinolinedione; indolizinoquinolinedione derivatives; catalytic inhibitors ... See more keywords