Novel synthesis of biologically active indolo [3,2-C] isoquinoline derivatives
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DOI: 10.1016/j.arabjc.2014.07.009
Abstract: Abstract Indole-2-carboxylates are refluxed with hydrazine hydrate to form 5-substituted-3-phenylindole-2-carboxyhydrazides. These are again converted to corresponding indole-2-carboxyazides. Azides are further converted into carbamates and finally these carbamates are cyclized to form the respective substituted 6H,… read more here.
Keywords: active indolo; synthesis biologically; indolo isoquinoline; isoquinoline derivatives ... See more keywords
The synthesis of anticancer sulfonated indolo[2,1-a]isoquinoline and benzimidazo[2,1-a]isoquinolin-6(5H)-ones derivatives via a free radical cascade pathway
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DOI: 10.1039/d1ra06981k
Abstract: A facile CuBr2 induced radical relay addition/cyclization of activated alkenes with substituted-thiosulfonates has been achieved, leading to a broad range of sulfonated indolo[2,1-a]isoquinolines and benzimidazo[2,1-a]isoquinolin-6(5H)-ones in moderate to good yields. In particular, some compounds exhibit… read more here.
Keywords: synthesis anticancer; indolo isoquinoline; anticancer sulfonated; isoquinolin ones ... See more keywords