Chemoselective synthesis of bis(indolyl)methanes using sulfonic acid-functionalized chitosan
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Papers"
DOI: 10.1007/s11696-019-00846-2
Abstract: Herein, we describe the electrophilic substitution reaction of indole with aldehydes and ketone using sulphonic acid functional group containing chitosan for the synthesis of bis(indolyl)methanes. The reaction is chemoselective affording a product from aldehydes and… read more here.
Keywords: indolyl methanes; synthesis bis; bis indolyl;
Green and efficient synthesis of aryl/alkylbis(indolyl)methanes using Expanded Perlite-PPA as a heterogeneous solid acid catalyst in aqueous media
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DOI: 10.1007/s12039-017-1246-x
Abstract: AbstractExpanded Perlite-Polyphosphoric acid (EP-PPA) as a novel, efficient, recyclable and eco-benign heterogeneous catalyst has been applied for the green and rapid synthesis of aryl/alkylbis(indolyl)methanes, in water, in good to excellent yields. The catalyst was characterized… read more here.
Keywords: indolyl methanes; aryl alkylbis; catalyst; alkylbis indolyl ... See more keywords
Utilization of flow chemistry in catalysis: New avenues for the selective synthesis of Bis(indolyl)methanes
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2017.02.026
Abstract: Abstract Flow chemistry enables the preparation of bis(indolyl)methanes from various indoles and structurally divergent aldehydes using Sc(OTf) 3 catalysis. The reaction is regioselective for C-3 functionalization of the indoles, occurring over short reaction times allowing… read more here.
Keywords: indolyl methanes; flow chemistry; chemistry; bis indolyl ... See more keywords
Catalytic Enantioselective Synthesis of 2,3'-Bis(indolyl)methanes Bearing All-Carbon Quaternary Stereocenters via 2-Indole Imine Methides.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.2c04109
Abstract: An organocatalytic enantioselective formal hydroarylation of 2-vinyl indoles for the preparation of enantioenriched 2,3'-bis(indolyl)methanes bearing an all-carbon quaternary stereocenter is described. This reaction features mild conditions, low catalyst loading, excellent efficiency and enantioselectivity. The obtained… read more here.
Keywords: bearing carbon; indolyl methanes; carbon quaternary; bis indolyl ... See more keywords
Effective Synthesis and Biological Evaluation of Natural and Designed Bis(indolyl)methanes via Taurine-Catalyzed Green Approach
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DOI: 10.1021/acsomega.1c07258
Abstract: An ecofriendly, inexpensive, and efficient route for synthesizing 3,3′-bis(indolyl)methanes (BIMs) and their derivatives was carried out by an electrophilic substitution reaction of indole with structurally divergent aldehydes and ketones using taurine and water as a… read more here.
Keywords: effective synthesis; synthesis biological; indolyl methanes; biological evaluation ... See more keywords
Supported Iridium Catalyst for the Green Synthesis of 3,3′-Bis(indolyl)methanes Using Methanol As the Bridging Methylene Source
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DOI: 10.1021/acssuschemeng.9b00094
Abstract: The first example of a heterogeneous catalyst based on hydrotalcite-derived Mg–Al oxides supported iridium (Ir/MgxAlO) for activation of methanol in the synthesis of bis(indolyl)methanes (BIMs) is reported. In this clean and reusable iridium-based catalytic system,… read more here.
Keywords: synthesis; indolyl methanes; supported iridium; catalyst ... See more keywords
Recent Developments on the Synthesis of Biologically Significant bis/tris(indolyl)methanes under Various Reaction Conditions: A Review
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DOI: 10.2174/1385272824666200228092752
Abstract: Bis(indolyl)methane skeleton is the main building block of many naturally occurring bioactive compounds. Bis(indolyl)methanes are found to possess a wide range of pharmaceuitical efficacies. These important scaffolds are being used as anti-cancer, antioxidant, anti-bacterial, anti-inflammatory,… read more here.
Keywords: indolyl methanes; bis tris; developments synthesis; various reaction ... See more keywords
Synthesis and Biological Evaluation of Heterocyclic Substituted Bis(indolyl)methanes.
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DOI: 10.2174/1570179417666200124103400
Abstract: Bis(indolyl)methane derivatives, also considering as metabolites of indole alkaloids, are widely found in nature with a broad range of biological and pharmacological activities. In this work, a series of heterocyclic substituted bis(indolyl)methanes (3a-3p) have been… read more here.
Keywords: indolyl methanes; bis indolyl; substituted bis; heterocyclic substituted ... See more keywords