Development of a Water-Soluble Indolylmaleimide Derivative IM-93 Showing Dual Inhibition of Ferroptosis and NETosis
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DOI: 10.1021/acsmedchemlett.9b00142
Abstract: The indolylmaleimide (IM) derivative IM-17 shows inhibitory activity against oxidative-stress-induced necrotic cell death and cardioprotective activity in rat ischemia-reperfusion injury models. In order to develop a more potent derivative, we conducted a detailed structure–activity relationship… read more here.
Keywords: indolylmaleimide derivative; ferroptosis netosis; water; netosis ... See more keywords