Construction of Novel Tetrahydro‐β‐carboline‐1‐thione Spirooxindoles by Brønsted Acid Mediated Formal [3+3] Cyclization of 3‐Indolylmethanols with 3‐Isothiocyanato Oxindoles
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DOI: 10.1002/jhet.2708
Abstract: p-Toluenesulfonic acid mediated formal [3+3] cyclization of 3-indolylmethanols with 3-isothiocyanato oxindoles was realized. This transformation allowed for the synthesis of a series of novel tetrahydro-β-carboline-1-thione spirooxindoles in moderate to excellent yields (up to 99%) with… read more here.
Keywords: acid mediated; mediated formal; indolylmethanols isothiocyanato; cyclization indolylmethanols ... See more keywords