Indomethacin decreases insulin secretion by reducing KCa3.1 as a biomarker of pancreatic tumor and causes apoptotic cell death
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22488
Abstract: Insulinomas originate from pancreatic β cells and it is the most widely known tumor. Indomethacin is a nonsteroidal anti‐inflammatory drug, which is used for blocking the production of some natural substances that cause inflammation and… read more here.
Keywords: secretion; insulin secretion; apoptotic cell; indomethacin ... See more keywords
Effect of nitric oxide-releasing derivative of indomethacin on Prevotella intermedia lipopolysaccharide-induced production of proinflammatory mediators in murine macrophages.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.08.055
Abstract: The purpose of this study was to investigate the influences of NCX 2121, a nitric oxide (NO)-releasing derivative of indomethacin, upon the generation of proinflammatory mediators using murine macrophages activated by lipopolysaccharide (LPS) isolated from… read more here.
Keywords: ncx 2121; murine macrophages; indomethacin; intermedia lps ... See more keywords
A comprehensive time course and correlation analysis of indomethacin-induced inflammation, bile acid alterations and dysbiosis in the rat small intestine.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2021.114590
Abstract: It has been proposed that changes in microbiota due to nonsteroidal anti-inflammatory drugs (NSAIDs) alter the composition of bile, and elevation of hydrophobic secondary bile acids contributes to small intestinal damage. However, little is known… read more here.
Keywords: bile; bile acids; indomethacin induced; indomethacin ... See more keywords
Involvement of nitric oxide pathway in the anti-inflammatory effect of modafinil on indomethacin-, stress-, and ethanol -induced gastric mucosal injury in rat
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2020.173579
Abstract: Gastric ulcer is a prevalent disease with various etiologies, including non-steroidal anti-inflammatory drugs (NSAIDs), stress conditions, and alcohol, resulting in an inflammatory condition in the gastric mucosa. The aim of this study was to explore… read more here.
Keywords: anti inflammatory; modafinil; stress; indomethacin ... See more keywords
Smart nanoparticles based on pullulan-g-poly(N-isopropylacrylamide) for controlled delivery of indomethacin.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2016.10.064
Abstract: Double hydrophilic thermo-responsive pullulan-g-poly(N-isopropylacrylamide) (P-g-pNIPAM) copolymers with two different molecular weight of thermosensitive grafts were synthesized and used for preparation of indomethacin-loaded nanoparticles by dialysis and nanoprecipitation method. The polymers form aggregates in aqueous solution… read more here.
Keywords: poly isopropylacrylamide; pullulan poly; indomethacin; drug ... See more keywords
Decarboxylation of indomethacin induced by heat treatment
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.04.022
Abstract: ABSTRACT As crystalline indomethacin is heated and subsequently cooled, it transforms into glassy indomethacin. While the original crystals are off‐white in color, the glass becomes blackish‐brown via a yellow intermediate stage. TLC of the components… read more here.
Keywords: hypoxic conditions; indomethacin induced; indomethacin; blackish brown ... See more keywords
Undesired co‐amorphisation of indomethacin and arginine during combined storage at high humidity conditions
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.04.026
Abstract: Graphical abstract Figure. No Caption available. Abstract The use of co‐amorphous systems for solubility enhancement of poorly water‐soluble drugs has recently gained interest in the field of pharmaceutical technology. However, undesired co‐amorphisation of a drug… read more here.
Keywords: storage; undesired amorphisation; indomethacin; indomethacin arginine ... See more keywords
Cobalt complexes of the non-steroidal anti-inflammatory drug indomethacin: Synthesis and structural studies
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DOI: 10.1016/j.molstruc.2020.129305
Abstract: Abstract Two new mixed ligand Co(II) complexes of the non-steroidal anti-inflammatory drug indomethacin (indo), viz. [Co(indo)2(H2O)4]∙2H2O;CI-1, [Co(indo)(imi)2Cl];CI-2, (where indo = indomethacin [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1Hindole-3-acetic acid)], and imi = imidazole), have been synthesized and characterized. The monodentate coordination of the carboxylato oxygen… read more here.
Keywords: non steroidal; steroidal anti; complexes non; anti inflammatory ... See more keywords
A Comparison of Drug Release and Adsorption Under Supersaturating Conditions for Ordered Mesoporous Silica with Indomethacin or Indomethacin Methyl Ester.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.0c00489
Abstract: Incomplete drug release from mesoporous silica systems has been observed in several studies. This work aims to increase understanding of this phenomenon by investigating the mechanism of drug-silica interactions and adsorption behaviour from supersaturated aqueous… read more here.
Keywords: adsorption; silica; drug; drug release ... See more keywords
Model for severe intracranial hemorrhage and role of early indomethacin in extreme preterm infants
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Research"
DOI: 10.1038/s41390-022-02012-z
Abstract: To develop a model for prediction of severe intracranial hemorrhage (ICH) or death based on variables from the first 12 h of age and to compare mortality and morbidities with and without exposure to early indomethacin.… read more here.
Keywords: intracranial hemorrhage; risk; indomethacin; early indomethacin ... See more keywords
Neuroprotective effect of indomethacin in normal perfusion pressure breakthrough phenomenon
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DOI: 10.1038/s41598-020-72461-1
Abstract: Loss of cerebral autoregulation in normal perfusion pressure breakthrough (NPPB) phenomenon has been reported in other Central Nervous System diseases such as neonatal intraventricular haemorrhage. Several studies have demonstrated that low-dose indomethacin prevents this latter… read more here.
Keywords: phenomenon; indomethacin; normal perfusion; perfusion pressure ... See more keywords