Protective Effect of Luminal Uric Acid Against Indomethacin-Induced Enteropathy: Role of Antioxidant Effect and Gut Microbiota
Sign Up to like & getrecommendations! Published in 2021 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-021-06848-z
Abstract: Uric acid (UA) has anti- and pro-inflammatory properties. We previously revealed that elevated serum UA levels provide protection against murine small intestinal injury probably via luminal UA secreted in the small intestine. Luminal UA may… read more here.
Keywords: microbiota; induced enteropathy; indomethacin induced; effect ... See more keywords
A comprehensive time course and correlation analysis of indomethacin-induced inflammation, bile acid alterations and dysbiosis in the rat small intestine.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2021.114590
Abstract: It has been proposed that changes in microbiota due to nonsteroidal anti-inflammatory drugs (NSAIDs) alter the composition of bile, and elevation of hydrophobic secondary bile acids contributes to small intestinal damage. However, little is known… read more here.
Keywords: bile; bile acids; indomethacin induced; indomethacin ... See more keywords
Hemicrania continua: Indomethacin induced myoclonus
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Neurology and Neurosurgery"
DOI: 10.1016/j.clineuro.2021.106703
Abstract: Myoclonus has been described rarely as an adverse effect with some non-steroidal anti-inflammatory drugs, but never with indomethacin. Indomethacin is a common nonsteroidal anti-inflammatory drug used for various primary headache disorders, including hemicrania continua. We… read more here.
Keywords: hemicrania; induced myoclonus; indomethacin induced; hemicrania continua ... See more keywords
Decarboxylation of indomethacin induced by heat treatment
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.04.022
Abstract: ABSTRACT As crystalline indomethacin is heated and subsequently cooled, it transforms into glassy indomethacin. While the original crystals are off‐white in color, the glass becomes blackish‐brown via a yellow intermediate stage. TLC of the components… read more here.
Keywords: hypoxic conditions; indomethacin induced; indomethacin; blackish brown ... See more keywords
Protective effects of camellia oil (Camellia brevistyla) against indomethacin-induced gastrointestinal mucosal damage in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2019.103539
Abstract: Abstract Accumulating evidence reveals that nonsteroidal anti-inflammatory drugs (NSAIDs), such as indomethacin, cause oxidative stress and inflammation, which consequently cause gastrointestinal (GI) mucosal damage. Camellia oil, a common edible oil used in Asia, has excellent… read more here.
Keywords: camellia oil; mucosal damage; indomethacin induced; oil ... See more keywords
The crucial role of neutrophil extracellular traps and IL-17 signaling in indomethacin-induced gastric injury in mice
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-95880-4
Abstract: The homeostasis of gastric mucosa is extremely delicate. Neutrophils, the most abundant immune cells in human circulation, are regarded crutial in the regulation of gastric mucosal immune response. Non-steroidal anti-inflammatory drugs (NSAIDs) induced gastric injury… read more here.
Keywords: gastric injury; injury; induced gastric; nets formation ... See more keywords
Effect of phylloquinone on indomethacin‐induced gastric ulceration in rats: Role of SIRT‐1
Sign Up to like & getrecommendations! Published in 2023 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13752
Abstract: Gastric ulcer is the most common gastrointestinal disorder affecting people globally. Although many drugs are available to treat ulcers, the mortality rate is relatively high, and drugs lack selectivity to treat ulcers without causing side… read more here.
Keywords: phylloquinone; sirt; indomethacin induced; induced gastric ... See more keywords
The effects of dragon fruit (Hylocereus polyrhizus) extract on indomethacin-induced stomach ulcer in rats.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of food biochemistry"
DOI: 10.1111/jfbc.14274
Abstract: The aim of this study was to investigate the effects of red dragon fruit (Hylocereus polyrhizus) extract (DFE) on the stomach in ulcer model induced by indomethacin in rats. Effects of DFE were evaluated in… read more here.
Keywords: extract; indomethacin; indomethacin induced; dragon fruit ... See more keywords
Long‐Term Pretreatment With D‐Limonene Protects Gastric Lipid Composition by Reducing Oxidative Damage and Inflammation in Indomethacin‐Induced Gastric Injury
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Food Biochemistry"
DOI: 10.1155/jfbc/6639397
Abstract: D‐Limonene is a monoterpene compound that is widely contained in citrus plants. It has been demonstrated to have several beneficial properties. The present study aimed to investigate the effect of D‐limonene against indomethacin‐induced gastric ulceration.… read more here.
Keywords: group; indomethacin; induced gastric; indomethacin induced ... See more keywords
Tamarix aphylla derived metabolites ameliorate indomethacin-induced gastric ulcers in rats by modulating the MAPK signaling pathway, alleviating oxidative stress and inflammation: In vivo study supported by pharmacological network analysis
Sign Up to like & getrecommendations! Published in 2024 at "PLOS ONE"
DOI: 10.1371/journal.pone.0302015
Abstract: Nature has proven to be a treasure resource of bioactive metabolites. In this regard, Tamarix aphylla (F. Tamaricaceae) leaves crude extract was investigated for its gastroprotective effect against indomethacin-induced damage to the gastric mucosa. Additionally,… read more here.
Keywords: aphylla; pharmacology; tamarix aphylla; mapk signaling ... See more keywords
A novel nano-formulation of olmesartan medoxomil with improved delivery and efficacy in the treatment of indomethacin-induced duodenitis in rats
Sign Up to like & getrecommendations! Published in 2023 at "Brazilian Journal of Medical and Biological Research"
DOI: 10.1590/1414-431x2023e12665
Abstract: There are few studies addressing duodenal inflammation. This study was designed to investigate the effects of a recently developed biotechnological product, a nano-formulation of olmesartan medoxomil (OM) - olmesartan medoxomil zeinmersomes (OMZ) - for the… read more here.
Keywords: induced duodenitis; duodenitis; olmesartan medoxomil; indomethacin induced ... See more keywords