DNA hypermethylation of sFRP5 contributes to indoxyl sulfate-induced renal fibrosis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-017-1538-0
Abstract: Renal fibrosis is the most common outcome of chronic kidney disease (CKD), while the pathogenesis of renal fibrosis is not fully understood. In this study, we first showed that the progress of renal fibrosis was… read more here.
Keywords: sfrp5; fibrosis; indoxyl sulfate; renal fibrosis ... See more keywords
Dual effects of the tryptophan-derived bacterial metabolite indole on colonic epithelial cell metabolism and physiology: comparison with its co-metabolite indoxyl sulfate.
Sign Up to like & getrecommendations! Published in 2022 at "Amino acids"
DOI: 10.1007/s00726-021-03122-4
Abstract: Indole, which is produced by the intestinal microbiota from L-tryptophan, is recovered at millimolar concentrations in the human feces. Indoxyl sulfate (IS), the main indole co-metabolite, can be synthesized by the host tissues. Although indole… read more here.
Keywords: colonic epithelial; indole; physiology; cell ... See more keywords
Association between the uremic toxins indoxyl-sulfate and p-cresyl-sulfate with sarcopenia and malnutrition in elderly patients with advanced chronic kidney disease
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2021.111266
Abstract: BACKGROUND in patients with chronic kidney disease (CKD) indoxyl sulfate (IS) and p-cresyl sulfate (PCs) may induce sarcopenia either directly or via systemic inflammation. We evaluated whether IS and PCs were associated with: sarcopenia, systemic… read more here.
Keywords: sarcopenia; malnutrition; chronic kidney; sulfate cresyl ... See more keywords
Role of uremic toxin indoxyl sulfate in the progression of cardiovascular disease
Sign Up to like & getrecommendations! Published in 2017 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.07.027
Abstract: &NA; The prevalence of cardiovascular disease (CVD) among patients with chronic kidney disease (CKD) is relatively high. Deterioration of renal function in CKD leads to accumulation of indoxyl sulfate, a tryptophan metabolite produced by gut… read more here.
Keywords: cardiovascular disease; progression; indoxyl sulfate; disease ... See more keywords
Apoptosis signal-regulating kinase 1 inhibition reverses deleterious indoxyl sulfate-mediated endothelial effects.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119267
Abstract: AIMS Indoxyl sulfate (IS), a protein-bound uremic toxin, is implicated in endothelial dysfunction, which contributes to adverse cardiovascular events in chronic kidney disease. Apoptosis signal regulating kinase 1 (ASK1) is a reactive oxygen species-driven kinase… read more here.
Keywords: regulating kinase; inhibition; apoptosis signal; signal regulating ... See more keywords
The effect of dihydroceramide desaturase 1 inhibition on endothelial impairment induced by indoxyl sulfate.
Sign Up to like & getrecommendations! Published in 2021 at "Vascular pharmacology"
DOI: 10.1016/j.vph.2021.106923
Abstract: Protein-bound uremic toxins (PBUTs) have adverse effects on vascular function, which is imperative in the progression of cardiovascular and renal diseases. The role of sphingolipids in PBUT-mediated vasculo-endothelial pathophysiology is unclear. This study assessed the… read more here.
Keywords: inhibition; effect dihydroceramide; indoxyl sulfate; dihydroceramide desaturase ... See more keywords
Evaluation of a new measurement method of indoxyl sulfate in hemodialysis patients
Sign Up to like & getrecommendations! Published in 2020 at "Therapeutic Apheresis and Dialysis"
DOI: 10.1111/1744-9987.13500
Abstract: Indoxyl sulfate (IS) is related to the development of cardiovascular disease and total mortality in dialysis patients. High‐performance liquid chromatography (HPLC) is the conventional measurement approach. However, the HPLC method is difficult to perform in… read more here.
Keywords: enzyme method; method; measurement; indoxyl sulfate ... See more keywords
Indoxyl sulfate reduces Ito,f by activating ROS/MAPK and NF-κB signaling pathways
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.145475
Abstract: There is a high prevalence of ventricular arrhythmias related to sudden cardiac death in patients with chronic kidney disease (CKD). To explored the possible mechanism of CKD-related ventricular arrhythmias, a CKD rat model was created,… read more here.
Keywords: indoxyl sulfate; activating ros; reduces ito; mapk signaling ... See more keywords
Prognostic Significance of Serum Indoxyl Sulfate and Albumin for Patients with Cardiovascular Disease.
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DOI: 10.1536/ihj.18-116
Abstract: The progression of renal dysfunction reduces serum albumin and deteriorates the binding capacity of protein-bound uremic toxins. We evaluated the prognostic implications of serum indoxyl sulfate (IS) and albumin levels in patients with cardiovascular disease.We… read more here.
Keywords: serum indoxyl; disease; indoxyl sulfate; sulfate albumin ... See more keywords
AST-120 Improves Cardiac Dysfunction in Acute Kidney Injury Mice via Suppression of Apoptosis and Proinflammatory NF-κB/ICAM-1 Signaling
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DOI: 10.2147/jir.s283378
Abstract: Purpose Acute kidney injury (AKI) is a devastating disorder associated with considerably high morbidity and mortality. Reports have shown that AST-120, an oral charcoal adsorbent, can reduce oxidative stress by lowering serum indoxyl sulfate levels.… read more here.
Keywords: kidney injury; indoxyl sulfate; ast 120; cardiac dysfunction ... See more keywords
The role of carbon adsorbent in the conservative management of chronic kidney disease.
Sign Up to like & getrecommendations! Published in 2017 at "Panminerva medica"
DOI: 10.23736/s0031-0808.16.03272-9
Abstract: Indoxyl sulfate is a uremic toxin, and cannot be removed efficiently by hemodialysis due to its protein-binding. Indoxyl sulfate induces cellular dysfunction by producing reactive oxygen species (ROS) such as superoxide by activating nicotinamide adenine… read more here.
Keywords: chronic kidney; indoxyl sulfate; ckd; ast 120 ... See more keywords