Mitochondrial carrier protein overloading and misfolding induce aggresomes and proteostatic adaptations in the cytosol
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e19-01-0046
Abstract: Previous studies in yeast showed that mitochondrial stressors not directly targeting the protein import machinery can cause mitochondrial precursor overaccumulation stress (mPOS) in the cytosol independent of bioenergetics. Here, we demonstrate mPOS and stress responses… read more here.
Keywords: carrier protein; mitochondrial carrier; mitochondrial proteins; induce ... See more keywords
Urate crystals directly activate the T-cell receptor complex and induce T-cell proliferation.
Sign Up to like & getrecommendations! Published in 2017 at "Biomedical reports"
DOI: 10.3892/br.2017.960
Abstract: Uric acid is a known danger associated molecular pattern molecule able to induce inflammation following internalization of its crystals by cells of the innate immune system. By activating antigen-presenting cells, urate boosts adaptive immunity as… read more here.
Keywords: cell proliferation; induce; proliferation; urate crystals ... See more keywords