HDAC4 mutations cause diabetes and induce β‐cell FoxO1 nuclear exclusion
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.602
Abstract: Studying patients with rare Mendelian diabetes has uncovered molecular mechanisms regulating β‐cell pathophysiology. Previous studies have shown that Class IIa histone deacetylases (HDAC4, 5, 7, and 9) modulate mammalian pancreatic endocrine cell function and glucose… read more here.
Keywords: diabetes induce; cause diabetes; induce cell; hdac4 mutations ... See more keywords
Bacterial genotoxins induce T cell senescence.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109220
Abstract: Several types of pathogenic bacteria produce genotoxins that induce DNA damage in host cells. Accumulating evidence suggests that a central function of these genotoxins is to dysregulate the host's immune response, but the underlying mechanisms… read more here.
Keywords: induce cell; cell senescence; senescence; genotoxins induce ... See more keywords
Neurotoxic reactive astrocytes induce cell death via saturated lipids.
Sign Up to like & getrecommendations! Published in 2021 at "Nature"
DOI: 10.1038/s41586-021-03960-y
Abstract: Astrocytes regulate the response of the central nervous system to disease and injury and have been hypothesized to actively kill neurons in neurodegenerative disease1-6. Here we report an approach to isolate one component of the… read more here.
Keywords: reactive astrocytes; saturated lipids; astrocytes induce; induce cell ... See more keywords
Chemotherapy to induce T-cell subpopulation changes in advanced breast cancer patients.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.e12562
Abstract: e12562Background: Recent data suggest that some anti-cancer agents may generate a stimulation of the immune system that can account for additional clinical responses. In breast cancer (BC) the immunomodulation via chemotherapy (CT) opens possible clinical… read more here.
Keywords: cancer; chemotherapy induce; induce cell; breast cancer ... See more keywords
The SARS-CoV-2 main protease doesn’t induce cell death in human cells in vitro
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0266015
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19) which has extremely rapidly spread worldwide. In order to develop the effective antiviral therapies, it is required to understand the… read more here.
Keywords: cell death; protease; main protease; induce cell ... See more keywords