Antibodies against Poly(ethylene glycol) Activate Innate Immune Cells and Induce Hypersensitivity Reactions to PEGylated Nanomedicines
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DOI: 10.1021/acsnano.2c12193
Abstract: Nanomedicines and macromolecular drugs can induce hypersensitivity reactions (HSRs) with symptoms ranging from flushing and breathing difficulties to hypothermia, hypotension, and death in the most severe cases. Because many normal individuals have pre-existing antibodies that… read more here.
Keywords: hypersensitivity reactions; anti peg; induce hypersensitivity; immune cells ... See more keywords