Rac1-GTPase regulates compression-induced actin protrusions (CAPs) of mesenchymal stem cells in 3D collagen micro-tissues.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2021.120829
Abstract: Cells can sense mechanical signals through cytoskeleton reorganization. We previously discovered the formation of omni-directional actin protrusions upon compression loading, namely compression-induced actin protrusions (CAPs), in human mesenchymal stem cells (MSCs) in 3D micro-tissues. Here,… read more here.
Keywords: compression; formation; induced actin; actin protrusions ... See more keywords
Myosin II proteins are required for organization of calcium-induced actin networks upstream of mitochondrial division.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e22-01-0005
Abstract: The formin INF2 polymerizes a calcium-activated cytoplasmic network of actin filaments, which we refer to as CIA (calcium-induced actin). CIA plays important roles in multiple cellular processes, including mitochondrial dynamics and vesicle transport. Here, we… read more here.
Keywords: mitochondrial division; myosin; induced actin; calcium ... See more keywords
Cofilin‐1–induced actin reorganization in stored platelets
Sign Up to like & getrecommendations! Published in 2020 at "Transfusion"
DOI: 10.1111/trf.15747
Abstract: During platelet storage, there are extensive changes in cytoskeleton and phosphatidylserine exposure. The intrinsic mitochondrial pathway of apoptosis, activated in stored platelets, is a major mediator these changes. Cofilin‐1 is an effector of actin reorganization.… read more here.
Keywords: reorganization stored; stored platelets; induced actin; actin reorganization ... See more keywords