Piezo1 channel‐mediated Ca2+ signaling inhibits lipopolysaccharide‐induced activation of the NF‐κB inflammatory signaling pathway and generation of TNF‐α and IL‐6 in microglial cells
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24311
Abstract: Microglial cells are crucial in maintaining central nervous system (CNS) homeostasis and mediating CNS disease pathogenesis. Increasing evidence supports that alterations in the mechanical properties of CNS microenvironments influence glial cell phenotypes, but the mechanisms… read more here.
Keywords: activation; microglial cells; piezo1 channel; ca2 signaling ... See more keywords
Planarization‐Induced Activation Wavelength Red‐Shift and Thermal Half‐Life Acceleration in Hydrazone Photoswitches
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DOI: 10.1002/open.201900340
Abstract: Abstract The optimization and modulation of the properties of photochromic compounds, such as their activation wavelengths and thermal relaxation half‐lives (τ 1/2), are essential for their adaptation in various applications. In this work, we studied… read more here.
Keywords: planarization; wavelength red; thermal half; activation wavelength ... See more keywords
Blimp1 suppressed CD4+ T cells‐induced activation of fibroblast‐like synoviocytes by upregulating IL‐10 via the rho pathway
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23672
Abstract: B lymphocyte‐induced maturation protein 1 (Blimp1) is a risk allele for rheumatoid arthritis (RA), but its functional mechanism in RA remains to be further explored. read more here.
Keywords: cd4 cells; suppressed cd4; activation fibroblast; cells induced ... See more keywords
Two promoter regions confer heat-induced activation of SlDREBA4 in Solanum lycopersicum.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.01.153
Abstract: Dehydration-responsive element binding (DREB) transcription factors activate the expression of downstream functional genes in combination with a dehydration-responsive element (DRE), and thereby improve the resistance of plants to abiotic stresses such as heat. However, the… read more here.
Keywords: heat induced; sldreba4; promoter; heat ... See more keywords
In Vivo Nonlinear Light Scattering Probe of Drug-Induced Activation of Bacterial Mechanosensitive Channels
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.3125
Abstract: The lack of homologues of the mechanosensitive (MS) channel of large conductance (MscL) in the human genome makes it a novel antimicrobial target. Specifically, MscL activators have been proposed as potential antibacterial species as they… read more here.
Keywords: transport; drug induced; mscl; light scattering ... See more keywords
Inhibitory effect of porphyran on lipopolysaccharide-induced activation of human immune cells.
Sign Up to like & getrecommendations! Published in 2020 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2019.115811
Abstract: In mice, porphyran extracted from Pyropia yezoensis exerts anti-inflammatory effects and suppresses lipopolysaccharide (LPS)-induced immune activation and sepsis. Here, we investigated inhibition of LPS-induced activation of human immune cells by porphyran and the underlying mechanisms.… read more here.
Keywords: lps induced; porphyran; activation human; human immune ... See more keywords
Probing temperature and capsaicin-induced activation of TRPV1 channel via computationally guided point mutations in its pore and TRP domains.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.04.239
Abstract: In a recent computational study, we revealed some mechanistic aspects of TRPV1 (transient receptor potential channel 1) thermal activation and gating and proposed a set of probable functionally important residues - "hot spots" that have… read more here.
Keywords: channel; trpv1 channel; activation; capsaicin induced ... See more keywords
UV-induced activation of organic chloramine: Radicals generation, transformation pathway and DBP formation.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of hazardous materials"
DOI: 10.1016/j.jhazmat.2021.126459
Abstract: Organic chloramines of little disinfection efficacy commonly exist in disinfection process (chlor(am)ination) due to the wide presence of organic amines in water, of which N-chlorodimethylamine (CDMA) is a typical one. For the first time, UV… read more here.
Keywords: photolysis; cdma; transformation; formation ... See more keywords
Effects of hydrophobicity, tethering and size on flow-induced activation of von Willebrand factor multimers.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2019.110050
Abstract: Von Willebrand factor (VWF) is a multimeric protein of blood plasma that mediates platelet adhesion to injury under strong hemodynamic flows in arterias and microvasvulature. We present a 3D coarse-grained computer model of VWF multimers… read more here.
Keywords: vwf multimers; von willebrand; activation; flow induced ... See more keywords
Low Energy Electron Induced C–H Activation Reactions in Methane Containing Ices
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Physical Chemistry C"
DOI: 10.1021/acs.jpcc.7b07348
Abstract: Conversion of alkanes to functionalized compounds is a highly sought after goal. Under high reaction temperatures, desired intermediate products like alcohols, aldehydes, and carboxylic acids are more easily oxidized to CO2 than the starting alkane,… read more here.
Keywords: electron induced; energy; energy electron; induced activation ... See more keywords
Oxygen as an Electron Scavenger: Its Role in Electron-Induced Activation of Coadsorbed Methane Embedded in Amorphous Solid Water
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Physical Chemistry C"
DOI: 10.1021/acs.jpcc.8b06388
Abstract: Low-energy electrons are known to play a fundamental role in activating small molecules in interstellar chemistry. Here we illustrate the electron-induced activation of the inert molecule methane while sandwiched between two 50 monolayers thick layers… read more here.
Keywords: oxygen; electron induced; chemistry; methane ... See more keywords