Rho‐kinase inhibitors protect against neonatal hyperoxia‐induced airway hyperreactivity in a rat pup model: Role of prostaglandin F2α
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Pulmonology"
DOI: 10.1002/ppul.25848
Abstract: Oxygen therapy in preterm neonates is associated with airway hyperreactivity. The role of Rho/Rho‐kinase smooth muscle signaling in hyperoxia‐induced airway hyperreactivity remains understudied. We hypothesized that inhibition of Rho‐kinase will attenuate airway hyperreactivity induced by… read more here.
Keywords: hyperoxia induced; rho kinase; induced airway; airway hyperreactivity ... See more keywords
1,25-Dihydroxyvitamin D3 targeting VEGF pathway alleviates house dust mite (HDM)-induced airway epithelial barrier dysfunction.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2016.11.004
Abstract: BACKGROUND In our previous studies, we have indentified that 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) can alleviate toluene diisocyanate-induced airway epithelial barrier disruption and we also found that vascular endothelial growth factor (VEGF) derived from airway epithelials cells… read more here.
Keywords: barrier; barrier dysfunction; airway epithelial; induced airway ... See more keywords
Unravelling the apoptotic mechanisms in T-lymphocytes in an animal model for pollen induced airway allergy and studying the impact of specific immunotherapy.
Sign Up to like & getrecommendations! Published in 2019 at "Immunobiology"
DOI: 10.1016/j.imbio.2018.11.008
Abstract: Asthma is a chronic inflammatory disorder of the airways, increasing in prevalence worldwide. Reduced T cell apoptosis may interfere with the down-regulation of an immune response resulting in T cell accumulation contributing to the chronic… read more here.
Keywords: immunotherapy; apoptosis; induced airway; pollen induced ... See more keywords
Icariside II attenuates eosinophils-induced airway inflammation and remodeling via inactivation of NF-κB and STAT3 in an asthma mouse model.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental and molecular pathology"
DOI: 10.1016/j.yexmp.2020.104373
Abstract: Asthma is a chronic inflammatory airway disease. Icariside II has been reported to exert anti-inflammatory effect in multiple human diseases. The present study aimed to investigate the effects and mechanisms of Icariside II on airway… read more here.
Keywords: airway inflammation; induced airway; inflammation remodeling; mouse model ... See more keywords
Chitinase-Induced Airway Hyperreactivity and Inflammation in a Mouse Model of Nonallergic Asthma
Sign Up to like & getrecommendations! Published in 2021 at "International Archives of Allergy and Immunology"
DOI: 10.1159/000513296
Abstract: Introduction: Environmental exposure to mites and fungi has been proposed to critically contribute to the development of IgE-mediated asthma. A common denominator of such organisms is chitin. Human chitinases have been reported to be upregulated… read more here.
Keywords: chitinase activity; chitinase induced; chitinase; induced airway ... See more keywords
The course of specific self-reported exercise-induced airway symptoms in adolescents with and without asthma
Sign Up to like & getrecommendations! Published in 2020 at "ERJ Open Research"
DOI: 10.1183/23120541.00349-2020
Abstract: Airway symptoms in conjunction with exercise can take on many forms and can have several contributory factors such as exercise-induced bronchoconstriction (EIB), exercise-induced laryngeal obstruction or hyperventilation [1]. Previous longitudinal studies on self-reported exercise-induced airway… read more here.
Keywords: exercise induced; reported exercise; induced airway; exercise ... See more keywords
Mechanistic Basis for Obesity‐related Increases in Ozone‐induced Airway Hyperresponsiveness in Mice
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the American Thoracic Society"
DOI: 10.1513/annalsats.201702-140aw
Abstract: Abstract Obesity is a risk factor for asthma, especially nonallergic asthma. Ozone, a common air pollutant, is a nonallergic asthma trigger. Importantly, ozone‐induced decrements in lung function are greater in obese and overweight human subjects… read more here.
Keywords: ozone induced; induced airway; mice; obesity ... See more keywords
A Selective α7 Nicotinic Acetylcholine Receptor Agonist, PNU-282987, Attenuates ILC2s Activation and Alternaria-Induced Airway Inflammation
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.598165
Abstract: Background The anti-inflammatory effect of an α7nAChR agonist, PNU-282987, has previously been explored in the context of inflammatory disease. However, the effects of PNU-282987 on type 2 innate lymphoid cells (ILC2s)-mediated allergic airway inflammation has… read more here.
Keywords: induced airway; pnu 282987; agonist pnu; airway inflammation ... See more keywords
Opuntia ficus-indica Alleviates Particulate Matter 10 Plus Diesel Exhaust Particles (PM10D)—Induced Airway Inflammation by Suppressing the Expression of Inflammatory Cytokines and Chemokines
Sign Up to like & getrecommendations! Published in 2022 at "Plants"
DOI: 10.3390/plants11040520
Abstract: Particulate matter (PM) exposure may cause adverse health effects such as respiratory disorders. We evaluated the protective effects of various Opuntia ficus-indica (OFI) extracts on airway inflammation associated with exposure to PM10D with an aerodynamic… read more here.
Keywords: induced airway; particulate matter; airway inflammation; ofi extracts ... See more keywords
Long noncoding RNA GAS5 attenuates cigarettesmoke-induced airway remodeling by regulatingmiR-217-5p/PTEN axis
Sign Up to like & getrecommendations! Published in 2022 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.3724/abbs.2022074
Abstract: Airway remodeling is a remarkable pathological characteristic of chronic obstructive pulmonary disease (COPD), and long noncoding RNAs have been demonstrated to participate in COPD development and pathogenesis. Here, we investigate the role of long noncoding… read more here.
Keywords: induced airway; rna gas5; long noncoding; airway remodeling ... See more keywords