Penehyclidine hydrochloride defends against LPS-induced ALI in rats by mitigating endoplasmic reticulum stress and promoting the Hes1/Notch1 pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2019.144095
Abstract: Penehyclidine hydrochloride (PHC) is a novel anticholinergic drug applied broadly in surgeries as a preanesthetic medication. A substantial amount of research indicates that PHC has lung defensive properties. Considering that endoplasmic reticulum (ER) stress exerts… read more here.
Keywords: phc; induced ali; lps induced; hes1 notch1 ... See more keywords
Protective effect of zerumbone reduces lipopolysaccharide‐induced acute lung injury via antioxidative enzymes and Nrf2/HO‐1 pathway
Sign Up to like & getrecommendations! Published in 2017 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2017.03.008
Abstract: Abstract Acute lung injury (ALI) is a serious disease with high morbidity and mortality rate. Although there are effective strategies for treatment of ALI; a widely accepted specific pharmacotherapy has not yet established. Zerumbone, the… read more here.
Keywords: induced ali; lps induced; acute lung; zerumbone ... See more keywords
NLRC3 Participates in Inhibiting the Pulmonary Inflammatory Response of Sepsis-Induced Acute Lung Injury.
Sign Up to like & getrecommendations! Published in 2023 at "Immunological investigations"
DOI: 10.1080/08820139.2023.2206445
Abstract: Acute lung injury (ALI) progresses rapidly, is difficult to treat, and has a high fatality rate. The excessive inflammatory response is an important pathological mechanism of ALI. NLRC3 (NLR family CARD domain-containing 3), a non-inflammasome… read more here.
Keywords: sepsis induced; inflammatory response; induced ali; lung ... See more keywords
SRPK1 promotes sepsis-induced acute lung injury via regulating PI3K/AKT/FOXO3 signaling
Sign Up to like & getrecommendations! Published in 2022 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2022.2134789
Abstract: Abstract Objective Sepsis is the most common cause of death in the intensive care unit. Moreover, sepsis is the leading cause of acute lung injury (ALI). Serine-arginine protein kinase 1 (SRPK1) was demonstrated to promote… read more here.
Keywords: sepsis; acute lung; via regulating; induced ali ... See more keywords
Arid2-IR downregulates miR-132-3p through methylation to promote LPS-induced ALI in pneumonia
Sign Up to like & getrecommendations! Published in 2022 at "Inhalation Toxicology"
DOI: 10.1080/08958378.2022.2102699
Abstract: Abstract Objective Arid2-IR is a long non-coding RNA (lncRNA) that promotes renal injury, while its role in lipopolysaccharides (LPS)-induced acute lung injury (ALI) is unknown. Our preliminary sequencing analysis revealed an inverse correlation of Arid2-IR… read more here.
Keywords: methylation; induced ali; pneumonia; mir 132 ... See more keywords
SIRT3 Deficiency Promotes Lung Endothelial Pyroptosis Through Impairing Mitophagy to Activate NLRP3 Inflammasome During Sepsis-Induced Acute Lung Injury
Sign Up to like & getrecommendations! Published in 2024 at "Molecular and Cellular Biology"
DOI: 10.1080/10985549.2024.2426282
Abstract: Abstract Acute lung injury (ALI) is a major cause of death in bacterial sepsis due to endothelial inflammation and endothelial permeability defects. Mitochondrial dysfunction is recognized as a key mediator in the pathogenesis of sepsis-induced… read more here.
Keywords: lung; sirt3 deficiency; sepsis induced; induced ali ... See more keywords
Lipoxin A4 ameliorates renal ischaemia–reperfusion‐induced acute lung injury in rats
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13023
Abstract: Lipoxin A4 (LA4), a bioactive product of arachidonic acid, has been shown to exert strong anti‐inflammatory activity. By contrast, the anti‐inflammatory action of LA4 in a renal ischaemia–reperfusion (RIR)‐mediated acute lung inflammation (ALI) model and… read more here.
Keywords: induced ali; rir induced; rir; renal ischaemia ... See more keywords
LTB4 Promotes Acute Lung Injury via Upregulating the PLCε-1/TLR4/NF-κB Pathway in One-Lung Ventilation
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/1839341
Abstract: Background Mechanical ventilation (MV) can provoke acute lung injury (ALI) by increasing inflammation activation and disrupting the barrier in lung tissues even causing death. However, the inflammation-related molecules and pathways in MV-induced ALI remain largely… read more here.
Keywords: induced ali; plc tlr4; lung; tlr4 ... See more keywords
Melatonin alleviates sepsis-induced acute lung injury by inhibiting necroptosis via reducing circulating mtDNA release
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Medicine"
DOI: 10.1186/s10020-025-01228-z
Abstract: Sepsis is a life-threatening condition that often leads to severe complications, including acute lung injury (ALI), which carries high morbidity and mortality in critically ill patients. Melatonin (Mel) has shown significant protective effects against sepsis-induced… read more here.
Keywords: mtdna; lung; necroptosis; sepsis induced ... See more keywords
FPR1-dependent Pro-inflammatory Ccl4high monocytes/macrophages drive and predict sepsis-induced acute lung injury
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DOI: 10.1186/s12931-025-03385-5
Abstract: The elusive pathogenesis of sepsis-induced acute lung injury (ALI) combined with the absence of reliable diagnostic biomarkers, significantly hinders the development of targeted therapies and precision medicine approaches for affected patients. In this study, we… read more here.
Keywords: induced acute; sepsis induced; acute lung; induced ali ... See more keywords
Frontline Science: D1 dopaminergic receptor signaling activates the AMPK‐bioenergetic pathway in macrophages and alveolar epithelial cells and reduces endotoxin‐induced ALI
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Leukocyte Biology"
DOI: 10.1189/jlb.3hi0216-068rr
Abstract: Catecholamines, including β‐adrenergic and dopaminergic neurotransmitters, have an essential role in regulating the “fight or flight” reflex and also affects immune cell proinflammatory action. However, little is known about whether catecholamines prevent dysfunction of metabolic… read more here.
Keywords: endotoxin induced; induced ali; epithelial cells; activation ... See more keywords