Antigen-Induced Allosteric Changes in a Human IgG1 Fc Increase Low-Affinity Fcγ Receptor Binding.
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DOI: 10.1016/j.str.2020.03.001
Abstract: Antibody structure couples adaptive and innate immunity via Fab (antigen binding) and Fc (effector) domains that are connected by unique hinge regions. Because antibodies harbor two or more Fab domains, they are capable of crosslinking… read more here.
Keywords: induced allosteric; low affinity; antigen; antigen induced ... See more keywords