Paeonol ameliorates monosodium urate‐induced arthritis in rats through inhibiting nuclear factor‐κB‐mediated proinflammatory cytokine production
Sign Up to like & getrecommendations! Published in 2019 at "Phytotherapy Research"
DOI: 10.1002/ptr.6472
Abstract: Moutan Cortex has been widely used to treat various types of arthritis in traditional Chinese medicine. Paeonol is isolated as an active ingredient from Moutan Cortex. However, the effect and potential mechanism of paeonol on… read more here.
Keywords: induced arthritis; paeonol; rats inhibiting; mia rats ... See more keywords
Levetiracetam mitigates lipopolysaccharide‐induced JAK2/STAT3 and TLR4/MAPK signaling pathways activation in a rat model of adjuvant‐ induced arthritis
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.02.041
Abstract: &NA; Levetiracetam (LEV), a novel anti‐epileptic drug that has been demonstrated with an anti‐inflammatory effect, but the exact mechanisms of its action remain to be fully defined. The present study aimed to evaluate the possible… read more here.
Keywords: induced arthritis; jak2 stat3; adjuvant induced; tlr4 ... See more keywords
PSTPIP2 attenuates joint damage and suppresses inflammation in adjuvant-induced arthritis.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172558
Abstract: Proline-serine-threonine-phosphatase-interacting protein 2 (PSTPIP2) is related to inflammation. In this study, we investigated the function of PSTPIP2 in adjuvant-induced arthritis (AIA) by using adeno-associated virus (AAV) to overexpress PSTPIP2 in rat. AIA rats were developed… read more here.
Keywords: induced arthritis; pstpip2; inflammation; adjuvant induced ... See more keywords
Ketoprofen and MicroRNA‐124 Co‐loaded poly (lactic‐co‐glycolic acid) microspheres inhibit progression of Adjuvant‐induced arthritis in rats
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.09.063
Abstract: ABSTRACT Ketoprofen, a non‐steroid anti‐inflammatory drug, is widely used for relieving the pain and swelling caused by rheumatoid arthritis. However, ketoprofen can’t suppress disease progression effectively. In this study, in an effort to improve the… read more here.
Keywords: induced arthritis; 124 loaded; arthritis rats; adjuvant induced ... See more keywords
Celastrol attenuates collagen-induced arthritis via inhibiting oxidative stress in rats.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106527
Abstract: The present work aimed to investigate the anti-rheumatism effect and the mechanism of celastrol in collagen-induced arthritis (CIA) rats. The CIA model was established in male Wistar rats by intradermal injection of bovine collagen-II in… read more here.
Keywords: induced arthritis; cia rats; celastrol; collagen induced ... See more keywords
TNFα-dependent anhedonia and upregulation of hippocampal serotonin transporter activity in a mouse model of collagen-induced arthritis
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.04.023
Abstract: &NA; The serotonin transporter (SERT) facilitates high affinity reuptake of 5‐HT from the extracellular fluid and dysregulation of transporter function has been implicated in a range of mood disorders including depression. Recent studies have linked… read more here.
Keywords: induced arthritis; serotonin transporter; transporter activity; activity ... See more keywords
The P2X7 Receptor, Cathepsin S and Fractalkine in the Trigeminal Subnucleus Caudalis Signal Persistent Hypernociception in Temporomandibular Rat Joints
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2018.09.005
Abstract: Temporomandibular joint (TMJ) is frequently involved with rheumatoid arthritis with a high prevalence that could result in a chronic pain state. Once the disease is established in the joint, the antigen-specific immune reaction initiates a… read more here.
Keywords: induced arthritis; hypernociception; cathepsin fractalkine; trigeminal subnucleus ... See more keywords
Anti-arthritic effect of pentosan polysulfate in rats with collagen-induced arthritis.
Sign Up to like & getrecommendations! Published in 2019 at "Research in veterinary science"
DOI: 10.1016/j.rvsc.2018.11.028
Abstract: Pentosan polysulfate (PPS) is currently under investigation as a potential disease-modifying antiarthritic agent. In the present study the effects of PPS on arthritic profiles based on clinical score, ankle size, histological changes, and activity of… read more here.
Keywords: induced arthritis; anti arthritic; arthritic rats; collagen induced ... See more keywords
Atractylodin Suppresses Dendritic Cell Maturation and Ameliorates Collagen-Induced Arthritis in a Mouse Model.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b01163
Abstract: The aim of this study was to evaluate the immunomodulatory effects of atractylodin, a polyethylene alkyne, on the maturation of bone marrow-derived dendritic cells (BM-DC) as well as its antirheumatic effect on collagen-induced arthritis (CIA)… read more here.
Keywords: induced arthritis; model; collagen induced; maturation ... See more keywords
Zerumbone Protects Rats from Collagen-Induced Arthritis by Inhibiting Oxidative Outbursts and Inflammatory Cytokine Levels
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c05749
Abstract: Rheumatoid arthritis (RA) is an immunocompromised disorder characterized by a marked increase in the synthesis of inflammatory molecules that stimulates the destruction of bones and cartilage. The conventional treatment modalities for RA are associated with… read more here.
Keywords: induced arthritis; collagen induced; zerumbone protects; inflammatory cytokine ... See more keywords
Therapeutic effects of matrine derivate MASM in mice with collagen-induced arthritis and on fibroblast-like synoviocytes
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-02423-7
Abstract: MASM is a matrine derivate that exhibits a number of pharmacological effects, including immunosuppressive activity and anti-inflammatory properties. In this study, the mechanisms underlying the therapeutic efficacy of MASM in the treatment of rheumatoid arthritis… read more here.
Keywords: induced arthritis; masm; mice collagen; collagen induced ... See more keywords