Piezoelectric Analgesia Blocks Cancer‐Induced Bone Pain
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Materials"
DOI: 10.1002/adma.202403979
Abstract: The manipulation of cell surface receptors’ activity will open a new frontier for drug development and disease treatment. However, limited by the desensitization of drugs, effective physical intervention strategy remains challenging. Here, the controllable internalization… read more here.
Keywords: bone pain; induced bone; cancer induced;
Bone‐Targeted Fluoropeptide Nanoparticle Inhibits NF‐κB Signaling to Treat Osteosarcoma and Tumor‐Induced Bone Destruction
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202412014
Abstract: Osteosarcoma is a malignant bone cancer usually characterized by symptoms of bone loss due to pathologically enhanced osteoclast activity. Activated osteoclasts enhance bone resorption and promote osteosarcoma cell progression by secreting various cytokines. Intercepting the… read more here.
Keywords: bone targeted; targeted fluoropeptide; fluoropeptide nanoparticle; induced bone ... See more keywords
Hesperetin suppresses RANKL‐induced osteoclastogenesis and ameliorates lipopolysaccharide‐induced bone loss
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27924
Abstract: Destructive bone diseases caused by osteolysis are increasing in incidence. They are characterized by an excessive imbalance of osteoclast formation and activation. During osteolysis, the activation of nuclear factor‐κB (NF‐κB) and mitogen‐activated protein kinase (MAPK)… read more here.
Keywords: induced osteoclastogenesis; induced bone; rankl induced; bone ... See more keywords
Radiation-Induced Bone Toxicity
Sign Up to like & getrecommendations! Published in 2017 at "Current Stem Cell Reports"
DOI: 10.1007/s40778-017-0099-z
Abstract: Purpose of ReviewNormal bone is commonly irradiated during radiation therapy (RT). The true impact of focal radiation on bone tissue remains unclear. The goal of this paper is to present the current understanding of radiation… read more here.
Keywords: induced bone; radiation induced; bone toxicity; bone ... See more keywords
Incidence of skeletal-related events in patients with breast or prostate cancer-induced bone metastasis or multiple myeloma: A 12-year longitudinal nationwide healthcare database study.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer epidemiology"
DOI: 10.1016/j.canep.2019.05.013
Abstract: BACKGROUND This study examined the incidence of skeletal-related events (SRE) among patients with breast cancer (BC)- or prostate cancer (PC)-induced bone metastasis or multiple myeloma (MM) based on a population-based, 12-year healthcare database. METHODS Patients… read more here.
Keywords: incidence; induced bone; year; metastasis ... See more keywords
Monotropein attenuates ovariectomy and LPS-induced bone loss in mice and decreases inflammatory impairment on osteoblast through blocking activation of NF-κB pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2018.06.015
Abstract: Estrogen deficiency and inflammation are known to play important roles in bone metabolism and occurrence of osteoporosis. Monotropein as an iridoid glycoside is reported to decrease estrogen deficiency-induced bone loss and inhibit inflammatory response in… read more here.
Keywords: lps induced; monotropein; induced bone; bone ... See more keywords
Sulforaphane alleviates hyperalgesia and enhances analgesic potency of morphine in rats with cancer-induced bone pain.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174412
Abstract: Due to the efficacy and tolerability of the available drugs, the current treatment for cancer-induced bone pain (CIBP) is not considered ideal, and new drugs are required for better treatment results. This study investigated whether… read more here.
Keywords: enhances analgesic; induced bone; bone; cancer ... See more keywords
Tubeimoside I suppresses diabetes-induced bone loss in rats, osteoclast formation, and RANKL-induced nuclear factor-κB pathway.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106202
Abstract: Type 2 diabetes mellitus is often companied with osteoporosis, a process which involves osteoclast activation. In this study, we found tubeimoside I, a natural compound isolated from the Chinese medicinal herb Bolbostemma paniculatum (Maxim) Franquet… read more here.
Keywords: induced bone; tubeimoside suppresses; osteoclast formation; suppresses diabetes ... See more keywords
Activation of the spinal EGFR signaling pathway in a rat model of cancer-induced bone pain with morphine tolerance
Sign Up to like & getrecommendations! Published in 2021 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2021.108703
Abstract: Cancer-induced bone pain (CIBP) is considered to be one of the most difficult pain conditions to treat. Morphine, an analgesic drug, is widely used in clinical practice, and long-term use of morphine can lead to… read more here.
Keywords: tolerance; induced bone; cancer; bone pain ... See more keywords
Reactive oxygen species scavengers ameliorate mechanical allodynia in a rat model of cancer-induced bone pain
Sign Up to like & getrecommendations! Published in 2018 at "Redox Biology"
DOI: 10.1016/j.redox.2017.10.011
Abstract: Cancer-induced bone pain (CIBP) is a frequent complication in patients suffering from bone metastases. Previous studies have demonstrated a pivotal role of reactive oxygen species (ROS) in inflammatory and neuropathic pain, and ROS scavengers exhibited… read more here.
Keywords: cibp; induced bone; bone; cancer induced ... See more keywords
Synergistic combinations of the dual enkephalinase inhibitor PL265 given orally with various analgesic compounds acting on different targets, in a murine model of cancer-induced bone pain
Sign Up to like & getrecommendations! Published in 2017 at "Scandinavian Journal of Pain"
DOI: 10.1016/j.sjpain.2016.09.011
Abstract: Abstract Background The first line pharmacological treatment of cancer pain is morphine and surrogates but a significant pain relief and a reduction of the side-effects of these compounds makes it necessary to combine them with… read more here.
Keywords: pl265; induced bone; cancer; receptor ... See more keywords