Chemically induced carcinogenesis in rodent models of aging: assessing organismal resilience to genotoxic stressors in geroscience research
Sign Up to like & getrecommendations! Published in 2019 at "GeroScience"
DOI: 10.1007/s11357-019-00064-4
Abstract: There is significant overlap between the cellular and molecular mechanisms of aging and pathways contributing to carcinogenesis, including the role of genome maintenance pathways. In the field of geroscience analysis of novel genetic mouse models… read more here.
Keywords: carcinogenesis; research; induced carcinogenesis; resilience genotoxic ... See more keywords
Cooperation between NRF2-mediated transcription and MDIG-dependent epigenetic modifications in arsenic-induced carcinogenesis and cancer stem cells.
Sign Up to like & getrecommendations! Published in 2021 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2021.03.030
Abstract: Environmental exposure to arsenic, a well-established carcinogen linked to a number of human cancers, is a public health concern in many areas of the world. Despite extensive studies on the molecular mechanisms of arsenic-induced carcinogenesis,… read more here.
Keywords: cancer stem; induced carcinogenesis; arsenic induced; stem ... See more keywords
Enhanced glycolysis, regulated by HIF-1&agr; via MCT-4, promotes inflammation in arsenite-induced carcinogenesis
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DOI: 10.1093/carcin/bgx034
Abstract: Arsenite is well established as a human carcinogen, but the molecular mechanisms leading to arsenite-induced carcinogenesis are complex and elusive. Accelerated glycolysis, a common process in tumor cells called the Warburg effect, is associated with… read more here.
Keywords: mct; glycolysis; induced carcinogenesis; enhanced glycolysis ... See more keywords
The effect of modulation of gut microbiome profile on radiation-induced carcinogenesis and survival.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of radiation research"
DOI: 10.1093/jrr/rrac062
Abstract: Non-lethal doses of ionizing radiation (IR) delivered to humans because of terrorist events, nuclear accidents or radiotherapy can result in carcinogenesis. Means of protecting against carcinogenesis are lacking. We questioned the role of the gut… read more here.
Keywords: gut; carcinogenesis; radiation; gut microbiome ... See more keywords
Proteases and HPV-Induced Carcinogenesis
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DOI: 10.3390/cancers14133038
Abstract: Simple Summary Human papillomavirus (HPV) infection is a sexually transmitted disease with high prevalence worldwide. Although most HPV infections do not lead to cancer, some HPV types are correlated with the majority of cervical cancers,… read more here.
Keywords: hpv dependent; carcinogenesis proteases; hpv; hpv induced ... See more keywords
Epigenetic Regulation in Chromium-, Nickel- and Cadmium-Induced Carcinogenesis
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DOI: 10.3390/cancers14235768
Abstract: Simple Summary Environmental and occupational exposure to heavy metals are risk factors for cancers. However, the molecular mechanisms of how heavy metals induce carcinogenesis are still not clear. In recent years, more and more studies… read more here.
Keywords: heavy metals; carcinogenesis; metal induced; angiogenesis ... See more keywords