Chrysophanol attenuated isoproterenol‐induced cardiac hypertrophy by inhibiting Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biology International"
DOI: 10.1002/cbin.11146
Abstract: Cardiac hypertrophy is a common pathological change found in various cardiovascular diseases. Although it has long been recognized as an important risk factor responsible for heart failure, there is still a lack of effective treatments… read more here.
Keywords: cardiac hypertrophy; transcription; induced cardiac; hypertrophy ... See more keywords
Fat‐1 transgenic mice rich in endogenous omega‐3 fatty acids are protected from lipopolysaccharide‐induced cardiac dysfunction
Sign Up to like & getrecommendations! Published in 2021 at "ESC Heart Failure"
DOI: 10.1002/ehf2.13262
Abstract: Cardiac malfunctions developing in result of sepsis are hard to treat so they eventually contribute to the increased mortality. Previous reports indicated for therapeutic potential of exogenous ω‐3 polyunsaturated fatty acids (PUFA) in sepsis, but… read more here.
Keywords: induced cardiac; mice rich; fatty acids; fat transgenic ... See more keywords
Prostaglandin E2 induced cardiac hypertrophy through EP2 receptor‐dependent activation of β‐catenin in 5/6 nephrectomy rats
Sign Up to like & getrecommendations! Published in 2021 at "ESC Heart Failure"
DOI: 10.1002/ehf2.13269
Abstract: Prostaglandin E2 (PGE2) is involved in the development of cardiac hypertrophy. However, whether PGE2 regulates the chronic kidney disease‐associated cardiac hypertrophy and the tentative mechanism remains to be elucidated. read more here.
Keywords: cardiac hypertrophy; induced cardiac; hypertrophy ep2; hypertrophy ... See more keywords
Pharmacological role of Vitamin C in stress‐induced cardiac dysfunction via alteration in Gut microbiota
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22986
Abstract: There is emerging evidence exhibiting the strong association of gut microbiota with cardiovascular metabolic functions. Cardiac diseases may alter the richness, diversity, and composition of the gut microbiome. Vitamin C (Vit C) plays an important… read more here.
Keywords: gut microbiota; role; vit; control ... See more keywords
Oral administration of alcalase potato protein hydrolysate‐APPH attenuates high fat diet‐induced cardiac complications via TGF‐β/GSN axis in aging rats
Sign Up to like & getrecommendations! Published in 2019 at "Environmental Toxicology"
DOI: 10.1002/tox.22651
Abstract: Consumption of high fat diet (HFD) is associated with increased cardiovascular risk factors among elderly people. Aging and obesity induced‐cardiac remodeling includes hypertrophy and fibrosis. Gelsolin (GSN) induces cardiac hypertrophy and TGF‐β, a key cytokine,… read more here.
Keywords: induced cardiac; tgf gsn; tgf; hypertrophy ... See more keywords
Calorie restriction changes lipidomic profiles and maintains mitochondrial function and redox balance during isoproterenol-induced cardiac hypertrophy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Physiology and Biochemistry"
DOI: 10.1007/s13105-021-00863-4
Abstract: Typically, healthy cardiac tissue utilizes more fat than any other organ. Cardiac hypertrophy induces a metabolic shift leading to a preferential consumption of glucose over fatty acids to support the high energetic demand. Calorie restriction… read more here.
Keywords: restriction; induced cardiac; cardiac hypertrophy; calorie restriction ... See more keywords
KLF15 protects against isoproterenol-induced cardiac hypertrophy via regulation of cell death and inhibition of Akt/mTOR signaling.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.03.087
Abstract: Increasing evidence indicate that the Krüppel-like factor KLF15, a member of Cys2/His2 zinc-finger DNA-binding proteins, attenuates cardiac hypertrophy. However, the role of KLF15 in cardiovascular system is largely unknown and the exact molecular mechanism of… read more here.
Keywords: cardiac hypertrophy; induced cardiac; mtor signaling; hypertrophy ... See more keywords
Plantamajoside attenuates isoproterenol-induced cardiac hypertrophy associated with the HDAC2 and AKT/ GSK-3β signaling pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2019.04.024
Abstract: As a compensatory response to cardiac overload, cardiac hypertrophy is closely associated with the occurrence and development of a variety of cardiovascular diseases, in which histone deacetylase 2 (HDAC2) has been reported to play an… read more here.
Keywords: cardiac hypertrophy; induced cardiac; hdac2 akt; hypertrophy ... See more keywords
Long‐term oral atazanavir attenuates myocardial infarction‐induced cardiac fibrosis
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.03.041
Abstract: ABSTRACT Atazanavir is an antiretroviral medication used to treat and prevent HIV/AIDS, but its effects on cardiac fibrosis are unknown. The aim of this study was to determine the effects of atazanavir on myocardial infarction… read more here.
Keywords: induced cardiac; myocardial infarction; cardiac fibrosis; infarction induced ... See more keywords
Matrine alleviates AGEs‐ induced cardiac dysfunctions by attenuating calcium overload via reducing ryanodine receptor 2 activity
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.10.010
Abstract: Abstract Featured by heart dysfunction, the diabetic cardiomyopathy is causing mortality and morbidity in type 2 diabetes mellitus patients. Matrine was considered as a cardioprotective agent. This study was aimed to investigate the therapeutic effects… read more here.
Keywords: induced cardiac; ages induced; cardiac dysfunctions; ryr2 ... See more keywords
Klotho inhibits angiotensin II-induced cardiac hypertrophy, fibrosis, and dysfunction in mice through suppression of transforming growth factor-β1 signaling pathway.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172549
Abstract: Recent studies have revealed critical roles of transforming growth factor-β1 (TGF-β1) and microRNA-132 (miR-132), a downstream mediator of TGF-β1, in the pathogenesis of cardiac remodeling. In this study, we tested whether the antiaging protein klotho… read more here.
Keywords: ang induced; induced cardiac; mir 132; growth factor ... See more keywords